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The Physiological Actions of LHRH — Evidence from the Hypogonadal (hpg) Mouse

  • H. M. Charlton
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The ultimate actions of a hormone can vary at different times during development and also at different sites in the body at any particular point in time. Provided that there is provision to prevent an overproduction of hormone from one site causing inappropriate physiological function at other sites then there is no reason to deny that the same molecule may indeed have widely disparate final actions at different sites in the body. The varied geography of the sites of somatostatin production and the different end physiological functions of this tetradecapeptide are a case in point.

Keywords

Preoptic Area Multiple Daily Injection Medial Preoptic Area Foetal Testis LHRH Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Akasu, T., Kojima, M., Koketsu, K. (1983) LHRH modulates nicotinic ACh-receptor sensitivity in amphibian cholinergic transmission (frog). Brain Res., 279: 347–51.PubMedCrossRefGoogle Scholar
  2. Aubert, M.L., Begeot, M., Winiger, B.P., Morel, G., Sigoneako, P.C. & Dubois, P.M. (1985) Ontogeny of hypothalamic LHRH and pituitary GnRH receptors in fetal and neonatal rats. Endocrinology, 116: 1565–76.PubMedCrossRefGoogle Scholar
  3. Begeot, M., Hemming, F.J., Martinat, N., Dubois, M.P. & Dubois P.M. (1983) GnRh stimulates immunoreactive lactotrope differentiation. Endocrinology, 112: 2224–6.PubMedCrossRefGoogle Scholar
  4. Carmel, P.W., Arai, S., & Ferin, M. (1976) Pituitary stalk portal blood-collection in rhesus monkeys: evidence for pulsatile release of gonadotrophin-releasing hormone (GnRH). Endocrinology, 99: 243–248.PubMedCrossRefGoogle Scholar
  5. Carr, F.E. & Chin, W.W. (1985) Absence of detectable chorionic gonadotrophic submit messenger ribonucleic acids in the rat placenta throughout gestation. Endocrinology, 116: 1151–7.PubMedCrossRefGoogle Scholar
  6. Cattanach, B.M., Iddon, C.A., Charlton, H.M., Chiappa, S.A., & Fink, G. (1977) Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature, 269: 338–340.PubMedCrossRefGoogle Scholar
  7. Charlton, H.M. (1985) The use of neural transplants to study neuroendocrine mechanisms. Frontiers in Neuroendocrinology, Vol. 9. Ed. W.F. Gangong & L. Martin. Raven Press (In press).Google Scholar
  8. Charlton, H.M., A. Speight, D.M.G. Halpin, A. Bramwell, W.J. Steward & G. Fink (1983b) Prolactin measurements in normal and hypogonadal (hpg) mice: developmental and experimental studies. Endocrinology, 113: 545–548.PubMedCrossRefGoogle Scholar
  9. Charlton, H.M., D.M.G. Halpin, C. Iddon, R. Rosie, G. Levy, I.F.W. McDowell, A. Megson, J.F. Morris, A. Bramwell, A. Speight, B.J. Ward, G. Davey-Smith & G. Fink (1983b) The effects of daily administration of single and multiple injections of gonadotrophin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse. Endocrinology, 113: 535–544.PubMedCrossRefGoogle Scholar
  10. Charlton, H.M., Parry, D.M. & Jones, A. (1985) Thy 1.1 and GnRH fibre output and physiological function in female hpg mice given pre-optic area grafts from foetal AKR mice. In: Neural grafting in the mammalian CNS, edited by A. Bjorklund, U. Stenevi, Elsevier. (637-641).Google Scholar
  11. Curtis, A., Lyons, V., & Fink, G. (1983) The human hypothalamic LHRH precursor is the same size as that in rat and mouse hypothalamus. Biochem. Biophys. Res. Comm., 117: 872–877.PubMedCrossRefGoogle Scholar
  12. Dluzen, D.E., Ramirez, V.D., Carter, C.S. & Getz, L.L. (1981) Male vole urine changes LH-RH and norepinephrine in female olfactory bulb. Science, 212: 573–5.PubMedCrossRefGoogle Scholar
  13. Dluzen, D.E. & Rameriz, V.D., (1983) Localised and discrete changes in neuropeptides (LHRH & TRH) and neurotransmitters (NE & DA) concentrations within the olfactory bulbs of male mice as a function of social interaction. Hormones of Behaviour, 17: 139–145.CrossRefGoogle Scholar
  14. Dorsa, D.M., Smith, E.R. & Davidson, J.M. (1981) Endocrine and behavioural effects of continuous exposure of male rats to a potent LHRH agonist: evidence for CNS actions of LHRH. Endocrinology, 109: 729–35.PubMedCrossRefGoogle Scholar
  15. Dudley, C.A., Vale, W., Rivier, J. & Moss, R.L. (1983) Facilitation of sexual receptivity in the female rat by a fragment of the LHRH decapeptide AC LHRH 5–10. Neuroendocrinology, 36: 486–8.PubMedCrossRefGoogle Scholar
  16. Gibson, M.J., Charlton, H.M., Perlow, M.J., Zimmerman, E.A., Davies, T.F & Krieger, D.T. (1984a) Preoptic area brain grafts in hypogonadal (hpg) female mice abolish effects of congenital hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency. Endocrinology, 114: 1938–1940.PubMedCrossRefGoogle Scholar
  17. Gibson, M.J., Krieger, D.T., Charlton, H.M., Zimmerman, E.A., Silverman, A.J. & Perlow, M.J. (1984b) Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Science, 225, 949–951.PubMedCrossRefGoogle Scholar
  18. Gorski, R.A. (1979) The neuroendocrinology of reproduction: an overview. Biol. Reprod., 20: 111–127.PubMedGoogle Scholar
  19. Halpin, D.M.G. (1984) Aspects of ovarian function in the mouse. D. Phil Thesis Oxford.Google Scholar
  20. Hsueh, A.J.W. & Jones, P.B.C. (1983) GnRH extrapituitary actions and Oaracrine control mechanisms. Ann. Rev. Physiol., 45: 83–94.CrossRefGoogle Scholar
  21. Jan, Y.N. & Jan, L.Y. (1983) A LHRH-like peptidergic neurotransmitter capable of ‘action at a distance’ in autonomic ganglia. Trends Neurosci., 6: 320–4.CrossRefGoogle Scholar
  22. Josso, N. (1981) Differentiation of the genital tract: stimulators and inhibitors. In Mechanisms of Sex Differentiation in Mammals, Ch. 5: 165–204. Eds. C.R. Austin & R.G. Edwards, Academic Press, London.Google Scholar
  23. Krieger, D.T., Perlow, M.J., Gibson, M.J., Davies, T.F., Zimmerman, E.A, Ferin, M., & Charlton, H.M. (1982) Brain grafts reverse hypogonadism of gonadotrophin releasing hormone deficiency. Nature, 298: 468–471.PubMedCrossRefGoogle Scholar
  24. Lee, J.N., Seppala, M. & Chard, T. (1981) Characterization of placental LH-releasing factor-like material. Acta Endocr. Copenh. 96: 394–7.Google Scholar
  25. Lyon, M.F., Cattanach, B.M. & Charlton, H.M. (1981) Genes affecting sex differentiation in mammals. In: Mechanisms of Sex Differentiation in Animals and Man: Ch. 9, pp. 367–374 Eds. C.R. Austin & R.G. Edwards, Academic Press, London.Google Scholar
  26. McDowell, I.F.W., Morris, J.F. & Charlton, H.M. (1982a) Characterization of the pituitary gonadotroph cells of hypogonadal (hpg) male mice: comparison with normal mice. J. Endocrinol., 95: 321–330.PubMedCrossRefGoogle Scholar
  27. McDowell, I.F.W., Morris, J.F., Charlton, H.M. & Fink, G. (1982b) Effects of luteinizing hormone releasing hormone on the gonadotrophs of hypogonadal (hpg) mice. J. Endocrinol., 95: 311–340.CrossRefGoogle Scholar
  28. Megson, A., Lewis, C.E., Morris, J.F., Charlton, H.M. & Fink, G. (1983) Heterogeneous responses to ‘pulsatile’ GnRH administration among the gonadotrophs of intact and castrate hpg mice. J. Anat., 137: 819–820, Abstr.Google Scholar
  29. Mills, T.M., Copland, J.A., Coy, D.H. & Schally, A.V. (1983) Is the postovulatory release of FSH in the rabbit mediated by LH-RH? Endocrinology, 113: 1020–4.PubMedCrossRefGoogle Scholar
  30. Mizunuma, H., Sampson, W.K., Lumpkin, M.D. & McCann, S.M. (1983) Evidence for an FSH-releasing factor in the posterior portion of the rat median eminence. Life Sci., 33: 2003–10.PubMedCrossRefGoogle Scholar
  31. Morris, J.F. & Charlton, H.M. (1983) Responses of gonadotrophs in female hypogonadal (hpg) mice to intracerebroventricular implantation of preoptic area tissue from normal mice. J. Anat., 137: 806–807, Abstr.Google Scholar
  32. Powers, C.A. & Johnson, D.C. (1984) Correlation of LH, FSH and GnRH release during various brain-pituitary coincubations. Horm. Res., 19: 117–26.PubMedCrossRefGoogle Scholar
  33. Riskind, P., & Moss, R.L. (1983) Midbrain LHRH infusions enhance lordotic behavior in ovariectomized estrogen-primed rats independently of a hypothalamic responsiveness to LHRH. Brain Res. Bull., 11: 481–5.PubMedCrossRefGoogle Scholar
  34. Riskind, P. & Moss, L.R. (1983b) Effects of lesions of putative LHRH-containing pathways and mid-brain nuclei on lordotic behavior and LH release in ovariectomized rats. Brain Res. Bull., 11: 493–500.PubMedCrossRefGoogle Scholar
  35. Sakuma, Y. & Pfaff, D.W. (1983) Modulation of the lordosis reflex of female rats by LHRH its antiserum and analogues in the mesencephalic grey. Neuroendocrinology, 36: 218–24.PubMedCrossRefGoogle Scholar
  36. Sarda, A.K. & Nair, R.M.G. (1981) Elevated levels of LRH in human milk. J. Clin. Endocr. Metab., 52: 826–8.PubMedCrossRefGoogle Scholar
  37. Sharpe, R.M. (1984) Intratesticular factors controlling testicular function. Biol. Reprod., 30: 29–49.PubMedCrossRefGoogle Scholar
  38. Smith-White, S. & Ojeda, S.R. (1983) Maternal modulation of infantile ovarian development via milk’ LHRH. Fed. Proceeding., 42: 978.Google Scholar
  39. Tan, L. & Rousseau, P. (1982) The chemical identity of the immunoreactive LHRH peptide biosynthesised in the human placenta. Biochem. Biophys. Res. Comm., 109: 1061–71.PubMedCrossRefGoogle Scholar
  40. Tepper, M.A. & Roberts, J.L. (1984) Evidence for only one B luteinising hormone and no B chorionic gonadotrophin gene in the rat. Endocrinology, 115: 385–391.PubMedCrossRefGoogle Scholar
  41. Ward, B.J. (1980) Some aspects of the reproductive physiology and behaviour of the hypogonadal (hpg) mouse. M. Sc. Thesis, Oxford.Google Scholar
  42. Ward, B.J. & Charlton, H.M. (1981) Female sexual behaviour in the GnRH deficient hypogonadal (hpg) mouse. Physiol. & Behavior., 27: 1107–1109.CrossRefGoogle Scholar
  43. Wilson et al. (1981) The role of gonadal steriods in sexual differentiation. Rec. Prog. Horm. Res., 37: 1–39.PubMedGoogle Scholar
  44. Witkin, J.W. & Silverman, A.J. (1983) LH-RH in rat olfactory systems. J. Comp. Neurol., 218: 426–32.PubMedCrossRefGoogle Scholar
  45. Witkin, J.W., Paden, C.M. & Silverman, A.J. (1982) The LHRH systems in the rat brain. Neuroendocrinology, 35: 429–38.PubMedCrossRefGoogle Scholar
  46. Yen, S.S.C., Tsai, C.C., Naftolin, F., Vanden Berg, G. & Ajabor, L. (1972) Pulsatile patterns of gonadotrophin release in subjects with and without ovarian function. J. Clin. Endocrinol. Metab. 34: 671–675.PubMedCrossRefGoogle Scholar
  47. Young, L.S., Detta, A., Clayton, R.N., Jones, A. & Charlton, H.M. (1985) Pituitary and gonadal function in hypogondadotrophic hypogonadal (hpg) mice bearing hypothalamic implants. J. Reprod. Fert., In Press.Google Scholar
  48. Young, L.S., Speight, A., Charlton, H.M. & Clayton, R.N. (1983) Pituitary gonadotrophin-releasing hormone receptor regulation in the hypogonadotropic hypogonadal (hpg) mouse. Endocrinology, 113, 55–61.PubMedCrossRefGoogle Scholar
  49. Young, L.S., A. Detta, R.N. Clayton, A. Jones & H.M. Charlton (1985) Pituitary and gonadal function in hypogonadotrophic hypogonadal (hpg) mice bearing hypothalamic implants. J. Reprod. Fert., 74: 247–255.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. M. Charlton
    • 1
  1. 1.Dept of Human AnatomyUniversity of OxfordOxfordUK

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