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Comparison of Protein and Ribonucleic Acid Composition of Post Mortem Brain Tissue Between Controls and Cases of Alzheimer Type Dementia

  • J. C. Pascall
  • N. M. Borthwick
  • A. Curtis
  • V. Lyons
  • C. M. Yates
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Alzheimer disease (AD) is an early onset dementia (patient under the age of 65 at the time of onset) characterized clinically by an initial loss of memory for recent events, with a later deterioration of cognition, memory and personality (Katzman, 1976; Terry & Davies, 1980; Wiskniewski & Iqbal, 1980). At a gross anatomical level, the brains of patients with AD are generally smaller than those of controls and usually show atrophy of the temporal and frontal lobes. At a histological level, the disorder is characterized by the presence of plaques, consisting of abnormal neurites associated with extracellular amyloid (Wisniewski & Terry, 1976; Tomlinson, 1982) and neurofibrillary tangles, comprised of paired helical filaments, which are concentrated in the perikarya (cell bodies) of neurones (Kidd, 1963; Tomlinson, 1982).

Keywords

Alzheimer Disease Temporal Cortex Neurofibrillary Tangle Cortical Grey Matter Paired Helical Filament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. C. Pascall
    • 1
  • N. M. Borthwick
    • 1
  • A. Curtis
    • 1
  • V. Lyons
    • 1
  • C. M. Yates
    • 1
  1. 1.MRC Brain Metabolism UnitRoyal Edinburgh HospitalEdinburghUK

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