Pituitary GnRH Receptors — Recent Studies and Their Functional Significance
The demonstration of GnRH receptor changes in a variety of physiological and abnormal states in animals has led to the general belief that these changes are functionally related to gonadotroph function. This idea was based largely on the apparently ‘tight’ qualitative positive correlation between GnRH receptor changes and changes in serum gonadotrophin levels in animals (reviewed in 1–3). That this may be an oversimplification was suggested by several lines of evidence derived either from in vitro studies in mice, or from in vitro studies designed to explore the cellular biochemical events involved in GnRH receptor regulation and action. This does not deny that GnRH receptors are a prerequisite for the hormone’s action in respective target tissues.
KeywordsPituitary Cell GnRH Antagonist GnRH Receptor GnRH Secretion Receptor Change
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