Ion Channels and the Control of Secretion in Normal Anterior Pituitary Cells

  • W. T. Mason
  • R. J. Bicknell
  • P. Cobbett
  • D. W. Waring
  • C. D. Ingram
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Secretion of the anterior pituitary hormones is controlled by peptides and amines synthesized and released by discrete neurones in the hypothalamus. The action of these factors in regulating hormone release is believed to involve changes in the electrical activity of the specific target cells (Douglas and Taraskevich, 1985). Because of the exceptional variety of different hormone-containing cell types in the anterior pituitary gland, most knowledge about the membrane properties which might be important in the regulation of hormone secretion from these cells has been derived from work using pituitary tumour cell lines as models.

Keywords

Pituitary Cell Rest Membrane Potential Intracellular Recording Anterior Pituitary Cell Membrane Patch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Conn, P.M. and Rogers, D.C., 1980, Gonadotropin release from pituitary cultures following activation of endogenous ion channels, Endocrinology, 107, 2133–2137.PubMedCrossRefGoogle Scholar
  2. Douglas, W.W. and Taraskevich, P.S., 1985, The electrophysiology of adenohypophysial cells, In: The electrophysiology of the secretory cell, Poisner and Trifaro (eds) Elsevier, Amsterdam, pp. 63–92.Google Scholar
  3. Dubinsky, J.M. and Oxford, G.S., 1984, Ionic currents in two strains of rat anterior pituitary tumour cells, J. Gen. Physiol., 83, 309–339.PubMedCrossRefGoogle Scholar
  4. Gross, D.S., 1984, The mammalian hypophysial pars tuberalis: a comparative iraraunocytochemical study, Gen. Comp. Endocrinol., 56, 283–291.PubMedCrossRefGoogle Scholar
  5. Gross, D.S., Turgeon, J.L. and Waring, D.W., 1984, The ovine pars tuberalis: a naturally occurring source of pure gonadotropes, Endocrinology, 114, 2084–2091.PubMedCrossRefGoogle Scholar
  6. Hagiwara, S. and Ohmori, H., 1982, Studies of calcium channels in rat clonal pituitary cells with patch electrode voltage clamp, J. Physiol., 331, 231–252.PubMedGoogle Scholar
  7. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. and Sigworth, F.J., 1981, Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pflugers Arch., 391, 85–100.PubMedCrossRefGoogle Scholar
  8. Ingram, C.D. and Mason, W.T., 1985, Intracellular recordings from putative lactotrophs of bovine pituitary: modulation of spontaneous action potentials by regulators of prolactin secretion, J. Physiol., 364, 52P.Google Scholar
  9. Israel, J-M., Denef, C. and Vincent, J-D., 1983, Electrophysiological properties of normal somatotrophs in culture: an intracellular study, Neuroendocrinology 37, 193–199.PubMedCrossRefGoogle Scholar
  10. Leong, D.A., Lau, S.K., Sinha, Y.N., Kaiser, D.L. and Thorner, M.O., 1985, Enumeration of lactotropes and somatotropes among male and female pituitary cells in culture: evidence in favor of a maramosomatotrope subpopulation in the rat. Endocrinology 116, 1371–1378.PubMedCrossRefGoogle Scholar
  11. Mason, W.T. and Waring, D.W., 1985, Electrophysiological recordings from gonadotrophs: evidence for Ca channels mediated by gonadotrophin-releasing hormone, Neuroendocrinology, 41, 258–268.PubMedCrossRefGoogle Scholar
  12. Mason, W.T. and Waring, D.W., 1986, Patch clamp recordings of single ion channel activation by gonadotrophin releasing hormone in ovine pituitary gonadotrophs, Neuroendocrinology, in press.Google Scholar
  13. Matteson, D.R. and Armstrong, C.M., 1984, Na and Ca channels in a transformed line of anterior pituitary cells. J. Gen. Physiol. 83, 371–394.PubMedCrossRefGoogle Scholar
  14. Saith, S., Bicknell, R.J. and Schofield, J.G., 1984, Different sodium requirements for Rb efflux and for growth hormone and prolactin secretion from bovine anterior pituitary cells, Mol. Cell. Endocrinol. 35, 47–54.PubMedCrossRefGoogle Scholar
  15. Schlegel, W. and Wollheim, C.B., 1984, Thyrotropin-releasing hormone increases cytosolic free Ca in clonal pituitary cells (GH3 cells): direct evidence for the mobilization of cellular calcium. J. Cell Biol. 99, 83–87.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • W. T. Mason
    • 1
  • R. J. Bicknell
    • 1
  • P. Cobbett
    • 1
  • D. W. Waring
    • 1
  • C. D. Ingram
    • 1
  1. 1.Department of NeuroendocrinologyA.F.R.C. Institute of Animal PhysiologyBabrahamUK

Personalised recommendations