Degradation of Luteinizing Hormone-Releasing Hormone (LHRH) by Pituitary Plasma Membrane and by Pituitary Cells in Culture
Luteinizing hormone releasing hormone (LHRH), a deca-peptide pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly NH2 is synthesized and released by the hypothalamus. It is carried via the portal blood vessels to the pituitary where it induces a cascade of reactions within the cell that results in the release of LH and FSH. The first step in the action of LHRH at the pituitary gland is its binding to high affinity cell surface receptors (Clayton and Catt, 1981; Meidan and Kochf 1981). Therefore the presence of pituitary plasma membrane-bound LHRH-degrading enzymes may be of potential physiological significance. These peptidases may be involved in the mechanism of action of LHRH, by regulating the amount and the duration of action of the decapeptide at its receptor site.
KeywordsHigh Pressure Liquid Chromatography Pituitary Cell Thyrotropin Release Hormone Luteinizing Hormone Release Hormone Plasma Membrane Fraction
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