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Biosynthesis of Somatostatin, Vasoactive Intestinal Polypeptide, and Thyrotropin Releasing Hormone

  • R. H. Goodman
  • M. R. Montminy
  • M. J. Low
  • T. Tsukada
  • S. Fink
  • R. M. Lechan
  • P. Wu
  • I. M. D. Jackson
  • G. Mandel
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The purpose of this review is to describe the recent advances in our understanding of the biosynthesis of three brain/gut peptides — somatostatin, vasoactive intestinal polypeptide, and thyrotropin releasing hormone. Although each of these hormones is found in both the brain and gastrointestinal tract, their physiology is quite distinct. Furthermore, each peptide poses a unique set of problems for isolating and characterizing its gene and gene products. This review focuses on the different molecular approaches that we have used to characterize the precursors of these three peptides. It further describes the more general techniques that we are currently using to examine the expression of the three genes.

Keywords

Vasoactive Intestinal Polypeptide Thyrotropin Release Hormone Thyrotropin Release Hormone High Molecular Weight Precursor Single Arginine Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. H. Goodman
    • 1
  • M. R. Montminy
    • 1
  • M. J. Low
    • 1
  • T. Tsukada
    • 1
  • S. Fink
    • 1
  • R. M. Lechan
    • 1
  • P. Wu
    • 2
  • I. M. D. Jackson
    • 2
  • G. Mandel
    • 1
  1. 1.Division of Endocrinology, Dept. of MedicineNew England Medical CenterBostonUSA
  2. 2.Division of EndocrinologyProvidence HospitalProvidenceUSA

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