Alcohol and Memory Impairment

  • Aman U. Khan
Part of the Critical Issues in Psychiatry book series (CIPS)


The effects of ethanol on the human body appear to be accumulative. Almost all the physiological systems of the body are affected by alcohol. Chronic consumption of alcohol causes diseases of the liver, pancreas, brain, gastrointestinal tract, and cardiovascular system. Organ sensitivity to alcohol varies widely. A few drinks a day, without producing acute intoxication, may cause liver disease in some persons while others may show no apparent effect. The nervous system, however, appears to be very sensitive to the toxic effects of alcohol.


Memory Impairment Memory Deficit Alcohol Intoxication Acute Intoxication Sensory Memory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Birnbaum I, Parker E: Acute effects of alcohol on storage and retrieval, in Birnbaum IM, Parker E (eds): Alcohol and Human Memory. Hillsdale, NJ, Laurence Erlbaum, 1977.Google Scholar
  2. Blusewicz M, Dustman R, Schenkenberg T, et al: Neuropsychological correlates of chronic alcoholism and aging. J Nery Ment Dis 1977; 165: 348–355.CrossRefGoogle Scholar
  3. Borg S, Kvande H, Sedvalle G: Central norepinephrine metabolism during alcohol intoxication in addicts and healthy volunteers. Science 1981; 213: 1135–1137.PubMedCrossRefGoogle Scholar
  4. Borisov MM: The role of serotonergic brain structures in alcohol addiction (English translation). Zh Nevropatol 1981; 81: 1094–1099.Google Scholar
  5. Calahan D: Problem Drinkers: A National Survey. San Francisco, Jossey-Bass, 1970.Google Scholar
  6. Carlen P, Wilkenson D, Wortzman G, et al: Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology 1981; 31: 377–385.PubMedGoogle Scholar
  7. Dmour M, Shahani B, Young R, et al: The importance of studying sural nerve conduction and late responses in the evaluation of alcoholic subjects. Neurology 1979; 29: 1600–1604.Google Scholar
  8. Drew G, Colquohoun W, Long H: Effects of small doses of alcohol on a skill resembling driving. Br Med J 1958; 2: 993–999.PubMedCrossRefGoogle Scholar
  9. Edmonds H Jr, Sylvester D,Bellin S, et al: Gamma-aminobutyric acid system and bioelectric activity of the brain in rats during alcohol intoxication. Fiziol Zh SSSR 1980; 16: 1298–1306.Google Scholar
  10. Eich JE: State-dependent retrieval of information in human episodic memory, in Birnbaum IM, Parker ES (eds): Alcohol and Human Memory. Hillsdale, NJ, Lawrence Erlbaum, 1977.Google Scholar
  11. Evans M, Martz R, Rodda B, et al: Quantitative relationship between blood alcohol concentration and psychomotor performance. Clin Pharmacol Ther 1974; 15: 253–260.PubMedGoogle Scholar
  12. Goodwin D, Hill S, Hopper S, et al: Alcoholic blackouts and Korsakoff syndrome, in Gross M (ed): Alcohol Intoxication and Withdrawal: Experimental Studies II. New York, Plenum Press, 1975.Google Scholar
  13. Guthrie A, Presley A, Greekie C, et al: The effects of alcohol on memory, in Sandler M (ed): Psychopharmacology of Alcohol. New York; Grune and Stratton, 1980, pp. 79–88.Google Scholar
  14. Hannon R, Day C, Butler A, et al: Alcohol consumption and cognitive functioning in college students. J Stud Alcohol 1983; 44: 283–298.PubMedGoogle Scholar
  15. Hiller J, Angel L, Simon E: Multiple opiate receptors: Alcohol selectively inhibits binding to deltan receptors. Science 1981; 214: 468–469.PubMedCrossRefGoogle Scholar
  16. Hollingshead A, Redlich F: Social Class and Mental Illness: A Community Survey. New York; John Wiley and Sons, 1958.Google Scholar
  17. Johnson N; Moderate drinkers suffer intellectual impairment. Alcohol Health Res World 1981–1982; 6:40.Google Scholar
  18. Jones B, Jones M: Women and alcohol: Intoxication, metabolism and the menstrual cycle, in Greenblatt M, Schuckit M (eds): Alcoholism Problems in Women and Children. New York, Crune and Stratton, 1976.Google Scholar
  19. Jones M, Jones B: Relationship of age and drinking history to the effects of alcohol on memory in women. J Stud Alcohol 1980; 41: 179–186.PubMedGoogle Scholar
  20. Kuriyama K, Rauscher G, Sze P: Effect of acute and chronic administration of ethanol on the 5hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain. Brain Res 1971; 26: 450–454.PubMedGoogle Scholar
  21. Lishman W, Ron M, Acker W: Computed tomography of the brain and psychomoter assessment of alcoholic patient—A British study, in Sandler M (ed): Psychopharmacology of Alcohol. New York, Crune and Stratton, 1980, pp. 33–41.Google Scholar
  22. Lisman SA: Alcoholic “blackout”: state-dependent learning? Arch Gen Psychiatry 1974; 30: 46–53.PubMedCrossRefGoogle Scholar
  23. MacVane J, Butters N, Montgomery K, et al: Cognitive functioning in new social drinkers. J Stud Alcohol 1982; 43: 81–95.PubMedGoogle Scholar
  24. Madill M: Alcohol Induced Dissociation in Humans: A Possible Treatment Technique for Alcoholism, PhD dissertation. Queens University (Kingston, Ontario, Canada ), 1967.Google Scholar
  25. Mello N, Mendelson J: Alcohol and human behavior, in Iverson LL, Iverson S, Snyder S (eds): Handbook of Psychopharmacology. New York, Plenum Press, 1978, vol 12.Google Scholar
  26. Miller WR, Saucedo C: Assessment of neuropsychological impairment and brain damage in problem drinkers, in Golden C, Moses J Jr, Coffman J, et al (eds): Clinical Neuropsychology. New York, Grune and Stratton, 1983, pp. 141–195.Google Scholar
  27. Mills K, Bisgrove E: Cognitive impairment and perceived risk from alcohol. J Stud Alcohol 1983; 44: 26–46.PubMedGoogle Scholar
  28. Moskowitz H, Depry D: Differential effect of alcohol on auditory vigilance and divided attention tasks. Q J Stud Alcohol 1968; 19: 54–63.Google Scholar
  29. Moskowitz H, Murray J: Alcohol and backward masking of visual information. J Stud Alcohol 1976; 37: 40–45.PubMedGoogle Scholar
  30. Naus M, Cermak L, De Luca D: Retrieval processes in alcoholic Korsakoff patients. Neuropsychologia 1977; 15: 737–742.PubMedCrossRefGoogle Scholar
  31. O’Leary M, Radford L, Chaney E, et al: Assessment of cognitive recovery in alcoholics by use of Trail-Making Test. J Clin Psychol 1977; 33: 579–582.PubMedCrossRefGoogle Scholar
  32. Owasoyo J, Iramain C: Effects of acute ethanol intoxication on the enzymes of the cholinergic system in mouse brain. Toxicol Lett 1981; 9: 267–270.PubMedCrossRefGoogle Scholar
  33. Parker E, Alkana R, Birnbaum I, et al: Alcohol and the disruption of cognitive processes. Arch Gen Psychiatry 1974; 31: 824–828.PubMedCrossRefGoogle Scholar
  34. Parker ES, Birnbaum I, Noble E: Alcohol and memory: Storage and state-dependency. J Verb Learn Verb Behav 1976; 15: 691–702.CrossRefGoogle Scholar
  35. Quijo J: Chronic alcoholics may suffer tissue damage in left brain. Alcoholism/Natl Mag 1981; 1: 45.Google Scholar
  36. Rawat AK: Brain levels and turnover rates of presumptive neurotransmitters as influenced by administration and withdrawal of ethanol in mice. J Neurochem 1974; 22: 915–922.PubMedCrossRefGoogle Scholar
  37. Reisberg RB: Stimulation of choline acetyltransferase activity by ethanol in in vitro preparations of rat cerebrum. Life Sci 1974; 14: 1965–1973.PubMedCrossRefGoogle Scholar
  38. Riege W, Holloway J, Kaplan D: Specific memory deficits associated with prolonged alcohol abuse. Alcohol Clin Exp Res 1981; 5: 378–385.PubMedCrossRefGoogle Scholar
  39. Riege W, Mildusak C, Buchhalter J: Material-specific memory impairments in chronic alcoholics. Biol Psychiatry 1976; 11: 109–113.PubMedGoogle Scholar
  40. Rosen L, Lee C: Acute and chronic effects of alcohol use on organizational processes in memory. J Abnorm Psychol 1976; 85: 309–317.PubMedCrossRefGoogle Scholar
  41. Ryback RS: The continuum and specificity of the effects of alcohol on memory: A review. Q J Stud Alcohol 1971; 32: 995–1016.PubMedGoogle Scholar
  42. Saucedo C: The Effects of Alcohol State-dependent Learning on an Encoding Variability Task: Clinical and Neuropsychological Implications, PhD dissertation. University of New Mexico, 1980.Google Scholar
  43. Sidell F, Pless J: Ethyl alcohol blood levels and performance decrements after oral administration to man. Psychopharmacologia 1971; 19: 246–261.PubMedCrossRefGoogle Scholar
  44. Sytinski I, Guzikov B, Gomanko M, et al: Gamma-aminobutyric acid system in brain during acute and chronic ethanol intoxication. J Neurochem 1975; 25: 43–48.CrossRefGoogle Scholar
  45. Talland GA: Deranged Memory. New York, Academic Press, 1965.Google Scholar
  46. Torvik A, Lindboe C, Rogde S: Brain lesions in alcoholics: A neuropathological study with clinical correlations. J Neurol Sci 1982; 56: 233–248.PubMedCrossRefGoogle Scholar
  47. Valchar M: Ucast dopaminergniho Systemu V Mechanismu Ucinku Psychofarmak Csl. Fysiol 1980; 29: 1–32.Google Scholar
  48. Victor M, Adams R, Collins G: The Wernicke-Korsakoff Syndrome. Blackwell, Oxford, 1971.Google Scholar
  49. Walker DW, Barnes D, Riley J, et al: Neurotoxicity of chronic alcohol consumption: An animal model, in Sandler M (ed): Psychopharmacology of Alcohol. New York, Grune and Stratton, 1980, pp. 17–31.Google Scholar
  50. Whalley LJ: Social and biological variables in alcoholism: A selective review, in Sandler M (ed): Psychopharmacology of Alcohol New York, Raven Press, 1980, pp 1–15.Google Scholar
  51. White W: Personality and cognitive learning among alcoholics with different intervals of sobriety. Psychol Rep 1965; 16: 1125–1140.CrossRefGoogle Scholar
  52. Williams R, Goldman M, Williams D: Alcohol due and expectancy effects on cognitive and motor performance. Paper presented at the annual meeting of the American Psychological Association Toronto, 1978.Google Scholar
  53. Young LD: Alcohol state-dependent effects in humans: A review and study of different task responses. Br J Alcohol Alcoholism 1979; 14: 100–105.Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Aman U. Khan
    • 1
  1. 1.Southern Illinois University School of MedicineSpringfieldUSA

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