Manipulation of Genes in Vitro and in Vivo

  • Dean H. Hamer
Part of the Basic Life Sciences book series


The genetic engineering of animals is by no means a new concept. Since the beginnings of history, man has attempted to improve his livestock and domestic animals through selective breeding. Such classical breeding schemes, though successful in many aspects, are limited by at least 2 major constraints. First, genetic information can be exchanged only between mem bers of the same or very closely related species. Second, these schemes depend on naturally occurring mutations or variants that may arise at very low frequencies.


Growth Hormone Intracellular Copper Virus Replicon CUP1 Gene CUP1 Promoter 


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  1. 1.
    Hamer, D.H., D.J. Thiele, and J.F. Lemontt (1985) Function and auto-regulation of yeast copperthionein. Science 228:685–690.PubMedCrossRefGoogle Scholar
  2. 2.
    Pavlakis, G.N., and D.H. Hamer (1983) Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus. Proc. Natl. Acad. Sci., USA 80:397–401.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dean H. Hamer
    • 1
  1. 1.Laboratory of BiochemistryNational Cancer InstituteBethesdaUSA

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