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The Effect of Inorganic Phosphate on Mitochondrial, Creatine Kinase

  • Norman Hall
  • Marlene DeLuca
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)

Abstract

Since the last meeting at Johns Hopkins in 1979, there has been a continued interest and a great deal of progress made in our understanding of the role of mitochondrial creatine kinase in muscle cells. The existence of the creatine phosphate shuttle as discussed by Bessman and Geiger (1) is now known to be an important aspect of muscle metabolism. There have been numerous studies on the effect of creatine kinase on respiration in heart muscle mitochondria. It is now well-documented that mitochondrial creatine kinase is responsible for stimulating respiration by utilizing ATP produced by oxidative phosphorylation and maintaining a constant high level of ADP available for continued phosphorylation. There has been much discussion about whether the ATP produced by oxidative phosphorylation is preferentially used by the mitochondrial creatine kinase. This aspect will be addressed by many of the other speakers here.

Keywords

Creatine Kinase Liver Mitochondrion Creatine Kinase Activity Heart Mitochondrion Breast Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Norman Hall
    • 1
  • Marlene DeLuca
    • 1
  1. 1.Departments of Medicine and ChemistryUniversity of California, San DiegoLa JollaUSA

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