Lessons for Muscle Energetics from 31P NMR Spectroscopy
The basic paradigm of muscle energetics has two aspects: (1) there is a net decrease in chemical potential energy content during muscular activity, the net reaction being the splitting of PCr; and (2) there is a recovery period after mechanical relaxation in which oxidative metabolism uses substrate to regenerate the initial pre-contraction steady-state levels of high-energy phosphate compounds, and so restores the initial chemical potential. At least under certain experimental conditions, it is possible to separate completely the processes occurring in the contraction phase (e.g., PCr splitting) from those occurring in the recovery phase (e.g., oxygen consumption above the basal rate).
KeywordsCreatine Kinase Soleus Muscle Extensor Digitorum Longus Contractile Activity Creatine Kinase Reaction
Unable to display preview. Download preview PDF.
- Edwards, R.H.T., Hill, D.K., and Jones, D.A., 1975, Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle, J. Physiol. (London), 251: 287.Google Scholar
- Gadian, D.G., 1982, “Nuclear Magnetic Resonance and its Application to Living Systems,” Clarendon, Oxford.Google Scholar
- Jacobus, W.E., and Ingwall, J.S., eds., 1980, “Heart Creatine Kinase,” Williams and Wilkins, Baltimore.Google Scholar
- Kushmerick, M.J., 1983, Energetics of muscle contraction, in: “Handbook of Physiology,” L. Peachey, R. Adrian, and S.R. Geiger, eds., American Physiological Society, Bethesda.Google Scholar
- Kushmerick, M.J., and Meyer, R.A., 1984, Chemical changes in rat leg muscle by 31P NMR, Am. J. Physiol. (Cell Physiol.), in press.Google Scholar
- Kushmerick, M.J., Meyer, R.A., and Brown, T.R., 1983, Phosphorus NMR spectroscopy of cat biceps and soleus muscles, in: “Oxygen Transport to Tissue,” vol. 4, H. I. Bicher and D.F. Bruley, eds., Plenum, New York.Google Scholar
- Meyer, R.A., Brown, T.R., and Kushmerick, M.J., 1984, NMR of fast-and slow-twitch muscle, Am. J. Physiol. (Cell Physiol.), in press.Google Scholar