Abstract
Since I have written recently published (Langer et al., 1982) or soon to be published (Langer, 1984) reviews on various aspects of calcium (Ca) compartmentation this report will serve as a brief summary of my present concepts of compartmentation with a focus on recent work from the Cardiovascular Research Laboratory at UCLA. These studies support the concept that Ca is distributed on and within the cell very differently dependent upon conditions of perfusion and functional demands.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bers, D.M., and Langer, G.A., 1979, Uncoupling cation effects on cardiac contractility and sarcolemmal Ca2+ binding. Am. J. Physiol. 237: H332 - H341
Bers, D.M., Philipson, K.D, and Langer, G.A., 1981, Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations. Am. J. Physiol. 240: H576 - H583
Burt, J.M., and Langer, G.A., 1983, Ca2+ displacement by Polymyxin B from sarcolemma isolated by “gas dissection” from cultured neonatal rat myocardial cells. Biochim. Biophys. Acta 729: 44–52
Burt, J.M., Duenas, C.J., and Langer, G.A., 1983, Influence of Polymyxin B, a probe for anionic phospholipids, on calcium binding and calcium and potassium fluxes of cultured cardiac cells. Circ. Res. 53: 679–687
Caroni, P., and Carafoli, E., 1981, The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification. J. Biol. Chem. 256: 3263–3270
Fabiato, A., 1983, Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am. J. Physiol. 245: C1 - C14
Fabiato, A., and Fabiato, F., 1978, Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat and frog hearts and from fetal and new-born rat ventricles. Am. J. Physiol. 307: 491–522
Langer, G.A., Frank, J.S., Nudd, L.M., and Seraydarian, K., 1976, Sialic acid: Effect of removal on calcium exchangeability of cultured heart cells. Science 193: 1013–1015
Langer, G.A., and Nudd, L.M., 1980, Addition and kinetic characterization of mitochondrial calcium in myocardial tissue culture. Am. J. Physiol. 239: H769 - H774
Langer, G.A., Frank, J.S., and Philipson, K.D., 1981, Correlation of alterations in cation exchange and sarcolemmal ultrastructure produced by neuraminidase and phospholipases in cardiac cell culture. Circ. Res. 49: 1289–1299
Langer, G.A., Frank, J.S., and Philipson, K.D., 1982, Ultrastr uc -ture and calcium exchange of the sarcolemma, sarcoplasmic reticulum and mitochondria of the myocardium. Pharmac. Therap. 16: 331–376
Langer, G.A., and Nudd, L.M., 1983, Effects of cations, phospholipases and neuraminidase on calcium binding to “gas dissected” membranes from cultured cardiac cells. Circ. Res. 53: 482–490
Langer, G.A., Rich, T.L., and Nudd, L.M., 1983, Calcium compartmentalization in cultured and adult myocardium: Activation of a caffeine-sensitive component. J. Mol. Cell. Cardiol. 15: 459–473
Langer, G.A., 1984, Calcium at the sarcolemma. J. Mol. Cell. Cardiol. 16: In press
Lehninger, A.L., 1974, Role of phosphate and other proton-donating anions in respiration-coupled transport of Ca2+ by mitochondria. Proc. Natl. Acad. Sci. 71: 1520–1524
Lüllman, H., and Peters, T., 1977, Plasmalemmal calcium in cardiac excitation-contraction coupling. Clin. Exp. Pharmacol. Physiol. 4: 49–57
Philipson, K.D., and Langer, G.A., 1979, Sarcolemmal bound calcium and contractility in the mammalian myocardium. J. Mol. Cell. Cardiol. 11: 857–875
Philipson, K.D., Bers, D.M., and Nishimoto, A.Y., 1980a, The role of phospholipids in the Ca2+ binding of isolated cardiac sarcolemma. J. Mol. Cell. Cardiol. 12: 1159–1173
Philipson, K.D., Bers, D.M. Nishimoto, A.Y., and Langer, G.A., 1980b, Binding of Ca2+ and Na+ to sarcolemmal membranes: relation to control of myocardial contractility. Am. J. Physiol. 238: H373 - H378
Philipson, K.D., and Nishimoto, A.Y., 1984, Stimulation of Nat-Ca2+ exchange in cardiac sarcolemmal vesicles by phospholipase D. J. Biol. Chem. In press
Ponce-Pornos, J.E., and Langer, G.A., 1982, Effects of inorganic phosphate on ion exchange, energy state, and contraction in mammalian heart. Am. J. Physiol. 242: H79 - H88
Ponce-Hornos, J.E., Langer, G.A., and Nudd, L.M., 1982, Inorganic phosphate: its effects on Ca exchange and compartmentalization in cultured heart cells. J. Mol. Cell. Cardiol. 14: 41–51
Robertson S.P., Potter, J.D., and Rouslin, W., 1982, The Ca2+ and Mg2+ dependence of Ca2+ uptake and respiratory function of porcine heart mitochondria. J. Biol. Chem. 257: 1743–1748
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Langer, G.A. (1986). Calcium Compartmentation in Mammalian Myocardium. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_40
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5107-8_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5109-2
Online ISBN: 978-1-4684-5107-8
eBook Packages: Springer Book Archive