Skip to main content

Calcium Compartmentation in Mammalian Myocardium

  • Chapter
Myocardial and Skeletal Muscle Bioenergetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 194))

  • 169 Accesses

Abstract

Since I have written recently published (Langer et al., 1982) or soon to be published (Langer, 1984) reviews on various aspects of calcium (Ca) compartmentation this report will serve as a brief summary of my present concepts of compartmentation with a focus on recent work from the Cardiovascular Research Laboratory at UCLA. These studies support the concept that Ca is distributed on and within the cell very differently dependent upon conditions of perfusion and functional demands.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bers, D.M., and Langer, G.A., 1979, Uncoupling cation effects on cardiac contractility and sarcolemmal Ca2+ binding. Am. J. Physiol. 237: H332 - H341

    PubMed  CAS  Google Scholar 

  • Bers, D.M., Philipson, K.D, and Langer, G.A., 1981, Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations. Am. J. Physiol. 240: H576 - H583

    PubMed  CAS  Google Scholar 

  • Burt, J.M., and Langer, G.A., 1983, Ca2+ displacement by Polymyxin B from sarcolemma isolated by “gas dissection” from cultured neonatal rat myocardial cells. Biochim. Biophys. Acta 729: 44–52

    Article  PubMed  CAS  Google Scholar 

  • Burt, J.M., Duenas, C.J., and Langer, G.A., 1983, Influence of Polymyxin B, a probe for anionic phospholipids, on calcium binding and calcium and potassium fluxes of cultured cardiac cells. Circ. Res. 53: 679–687

    PubMed  CAS  Google Scholar 

  • Caroni, P., and Carafoli, E., 1981, The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification. J. Biol. Chem. 256: 3263–3270

    CAS  Google Scholar 

  • Fabiato, A., 1983, Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am. J. Physiol. 245: C1 - C14

    PubMed  CAS  Google Scholar 

  • Fabiato, A., and Fabiato, F., 1978, Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat and frog hearts and from fetal and new-born rat ventricles. Am. J. Physiol. 307: 491–522

    CAS  Google Scholar 

  • Langer, G.A., Frank, J.S., Nudd, L.M., and Seraydarian, K., 1976, Sialic acid: Effect of removal on calcium exchangeability of cultured heart cells. Science 193: 1013–1015

    Article  PubMed  CAS  Google Scholar 

  • Langer, G.A., and Nudd, L.M., 1980, Addition and kinetic characterization of mitochondrial calcium in myocardial tissue culture. Am. J. Physiol. 239: H769 - H774

    PubMed  CAS  Google Scholar 

  • Langer, G.A., Frank, J.S., and Philipson, K.D., 1981, Correlation of alterations in cation exchange and sarcolemmal ultrastructure produced by neuraminidase and phospholipases in cardiac cell culture. Circ. Res. 49: 1289–1299

    PubMed  CAS  Google Scholar 

  • Langer, G.A., Frank, J.S., and Philipson, K.D., 1982, Ultrastr uc -ture and calcium exchange of the sarcolemma, sarcoplasmic reticulum and mitochondria of the myocardium. Pharmac. Therap. 16: 331–376

    Article  CAS  Google Scholar 

  • Langer, G.A., and Nudd, L.M., 1983, Effects of cations, phospholipases and neuraminidase on calcium binding to “gas dissected” membranes from cultured cardiac cells. Circ. Res. 53: 482–490

    PubMed  CAS  Google Scholar 

  • Langer, G.A., Rich, T.L., and Nudd, L.M., 1983, Calcium compartmentalization in cultured and adult myocardium: Activation of a caffeine-sensitive component. J. Mol. Cell. Cardiol. 15: 459–473

    Article  PubMed  CAS  Google Scholar 

  • Langer, G.A., 1984, Calcium at the sarcolemma. J. Mol. Cell. Cardiol. 16: In press

    Google Scholar 

  • Lehninger, A.L., 1974, Role of phosphate and other proton-donating anions in respiration-coupled transport of Ca2+ by mitochondria. Proc. Natl. Acad. Sci. 71: 1520–1524

    Article  PubMed  CAS  Google Scholar 

  • Lüllman, H., and Peters, T., 1977, Plasmalemmal calcium in cardiac excitation-contraction coupling. Clin. Exp. Pharmacol. Physiol. 4: 49–57

    Article  Google Scholar 

  • Philipson, K.D., and Langer, G.A., 1979, Sarcolemmal bound calcium and contractility in the mammalian myocardium. J. Mol. Cell. Cardiol. 11: 857–875

    Article  PubMed  CAS  Google Scholar 

  • Philipson, K.D., Bers, D.M., and Nishimoto, A.Y., 1980a, The role of phospholipids in the Ca2+ binding of isolated cardiac sarcolemma. J. Mol. Cell. Cardiol. 12: 1159–1173

    Article  PubMed  CAS  Google Scholar 

  • Philipson, K.D., Bers, D.M. Nishimoto, A.Y., and Langer, G.A., 1980b, Binding of Ca2+ and Na+ to sarcolemmal membranes: relation to control of myocardial contractility. Am. J. Physiol. 238: H373 - H378

    Google Scholar 

  • Philipson, K.D., and Nishimoto, A.Y., 1984, Stimulation of Nat-Ca2+ exchange in cardiac sarcolemmal vesicles by phospholipase D. J. Biol. Chem. In press

    Google Scholar 

  • Ponce-Pornos, J.E., and Langer, G.A., 1982, Effects of inorganic phosphate on ion exchange, energy state, and contraction in mammalian heart. Am. J. Physiol. 242: H79 - H88

    Google Scholar 

  • Ponce-Hornos, J.E., Langer, G.A., and Nudd, L.M., 1982, Inorganic phosphate: its effects on Ca exchange and compartmentalization in cultured heart cells. J. Mol. Cell. Cardiol. 14: 41–51

    Article  PubMed  CAS  Google Scholar 

  • Robertson S.P., Potter, J.D., and Rouslin, W., 1982, The Ca2+ and Mg2+ dependence of Ca2+ uptake and respiratory function of porcine heart mitochondria. J. Biol. Chem. 257: 1743–1748

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Langer, G.A. (1986). Calcium Compartmentation in Mammalian Myocardium. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5107-8_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5109-2

  • Online ISBN: 978-1-4684-5107-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics