The Effect of Creatine Analogue Substitution on the Post Tetanic Response of Fast Muscle

  • Graham W. Mainwood
  • Joanne Totosy de Zepetnek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


It is clear that creatine phosphate hydrolysis accounts for most of the heat + work generated during short bursts (1–2 sec) of muscular activity (Curtin and Woledge, 1978). The significance of ATP regeneration by this mechanism in terms of the contractile function of muscle is less clear. The ATP buffer function can be reduced or abolished by either creatine phosphate depletion or creatine kinase inhibitors such as FDNB (Cain Ğ Davies, 1962). Creatine phosphate depletion during ischemia (Gudbjarnason et al., 1970) or fatigue (Spande Ğ Schottelius, 1970) or treatment with FDNB all lead to suppressed contractile force in spite of the fact that a considerable amount of ATP is still present.


Normal Muscle Fast Muscle Transient Suppression Adenosine Phosphate Amphibian Skeletal Muscle 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Graham W. Mainwood
    • 1
  • Joanne Totosy de Zepetnek
    • 1
  1. 1.Department of PhysiologyUniversity of OttawaOttawaCanada

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