Abstract
Insulin is an anabolic hormone known to stimulate any synthetic pathway (Bessman, 1960). Its mechanism of action is still unknown. Bessman (1954, 1970) suggested that the effect of insulin on energy metabolism is accomplished by coupling the hexokinase reaction to the mitochondria, increasing the effectiveness of glucose conversion to glucose-6-phosphate. The ADP created in the reaction produces an acceptor effect on the mitochondria, increasing the rate of oxidative phosphorylation. Since high energy compounds are rate limiting substrates for anabolic reactions, an increase in supply can enhance all of them. The same argument is also valid for insulin’s favorable effect on membrane transport, also an energy requiring process.
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© 1986 Plenum Press, New York
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Zaidise, I., Geiger, P.J., Boehme, D., Bessman, S.P. (1986). Phosphorylated Nucleotides and Glycolytic Intermediates in Diabetic and Non-Diabetic Rat Uterus in Late Pregnancy. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_37
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DOI: https://doi.org/10.1007/978-1-4684-5107-8_37
Publisher Name: Springer, Boston, MA
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