The Effect of Reperfusion and Streptokinase on Ischemic Myocardium Serum Creatine Kinase Activity, MM Subtypes and Myocardial Blood Flow

  • Judy Mickelson
  • C. Jeffrey Carlson
  • Bianka Emilson
  • Elliot Rapaport
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


The amount of myocardium irreversibly damaged after coronary artery occlusion is of prognostic significance.1-4 Attempts to limit the extent of damage using streptokinase have been effective in reestablishing blood flow to ischemic myocardium.5-11 We were interested in the effect streptokinase has on ischemic myocardium distal to an occlusion when reperfusion occurs and the extent to which streptokinase affects myocardial reperfusion. We measured serum creatine kinase and its MM subtypes. These measurements are simple but indirect means of assessing infarct size that can be used clinically.4-12 However, when reperfusion occurs, serial serum creatine kinase activity is altered.10,13_15obtained more direct measurements of ischemia and subsequent reperfusion using radiolabeled microspheres to determine myocardial blood flow.16,17


Creatine Kinase Infarct Size Myocardial Blood Flow Myocardial Segment Coronary Artery Occlusion 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Judy Mickelson
    • 2
    • 1
  • C. Jeffrey Carlson
    • 2
    • 1
  • Bianka Emilson
    • 2
    • 1
  • Elliot Rapaport
    • 2
    • 1
  1. 1.Medical ServiceSan Francisco General HospitalSan FranciscoUSA
  2. 2.Cardiovascular Research InstituteUniversity of CaliforniaSan FranciscoUSA

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