Myocardial Acidosis and the Mitigation of Tissue ATP Depletion in Ischemic Cardiac Muscle: The Role of the Mitochondrial ATPase

  • William Rouslin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


A number of reports have now appeared demonstrating a marked inhibition of the mitochondrial oligomycin-sensitive ATPase as the result of the interruption of blood flow (ischemia) in a number of tissues including liver,1,2 kidney,3,4 skeletal muscle5 and cardiac muscle.6–9 By and large, the ATPase inhibition observed in ischemic tissues appears to be reversible if blood flow is resumed early enough,2,4,6,9 suggesting that this inhibition represents a regulatory response of the oligomycin-sensitive ATPase complex to one or more metabolic alterations within the ischemic cells.


ATPase Activity Left Circumflex Coronary Artery Shunt Tube Mitochondrial ATPase Coronary Sinus Ostium 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • William Rouslin
    • 1
  1. 1.Pharmacology and Cell BiophysicsUniversity of Cincinnati College of MedicineCincinnatiUSA

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