Compartmentation and Functional Mechanisms in Myocardial Failure and Myocardial Infarction

  • R. J. Bing
  • Y. Sasaki
  • M. Chemnitius
  • W. Burger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


Compartmentation is a term denoting confinement in space (anatomic compartmentation) and function (functional compartmentation). The result of compartmentation is functional specificity and maintenance of anatomic and functional integrity. Under pathologic conditions, spatial and functional integrity and specificity are obliterated. The extent and specificity of damage to anatomic and functional compartmentation depend on the cause of the pathologic condition. If this cause is well defined, the consequences are also clearly discernible. However, if there are several poorly defined causes, the functional changes are diffuse. Myocardial failure and myocardial infarction are cases in point. In the former, the causes are not clearly defined and thus changes in structure and function are poorly outlined. In myocardial infarction, due to regional ischemia both cause and effect are more easily defined. It is the purpose of this report to describe changes in compartmentation and specific mechanism in two conditions: myocardial failure and myocardial infarction.


Sarcoplasmic Reticulum Global Ischemia Regional Ischemia Myocardial Failure Regional Myocardial Ischemia 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. J. Bing
    • 1
  • Y. Sasaki
    • 1
  • M. Chemnitius
    • 1
  • W. Burger
    • 1
  1. 1.Huntington Medical Research InstitutesPasadenaUSA

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