Why is There a Delay in the Increased Oxygen Consumption during the Rest-Work Transition in Skeletal Muscle?

  • Richard J. Connett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


During the rest-work transition in skeletal muscle it has long been known that the increase in oxidative supply of ATP lags the increase in consumption of ATP. The balance is supplied by muscle stores of phosphocreatine (PCr) and glycolysis leading to accumulation of lactate in the muscle. Several hypotheses have been advanced to account for the lag in increase of \(\dot{V}{{O}_{2}}\). These have focused on limits to the delivery of substrates to the mitochondrion:
  1. 1)

    limiting oxygen supply

  2. 2)

    limiting supply of reducing equivalents

  3. 3)

    limiting ADP and/or phosphate (Pi)



Gracilis Muscle Adenine Nucleotide Translocase High Energy Phosphate Energy Turnover Creatine Kinase Reaction 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Richard J. Connett
    • 1
  1. 1.Department of PhysiologyUniversity of Rochester Medical CenterRochesterUSA

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