Energy Compartmentation and Active Transport in Proximal Kidney Tubules

  • Lazaro J. Mandel
  • Stephen P. Soltoff
  • Peter C. Brazy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 194)


The primary work of the kidney is active transport.1 It is a long-standing observation that a linear relationship exists between the rate of sodium reabsorption by the whole kidney and its rate of oxygen consumption.2,3 Since the oxygen is consumed at the mitochondria and the energy for active transport is used by the Na,K-ATPase located at the plasma membrane on the basolateral side, a basic question in cellular physiology concerns the mechanism whereby the two processes are linked. The answer to this question leads directly to energy compartmentation.


Proximal Tubule Sodium Pump Rabbit Kidney Cortical Tubule Proximal Kidney Tubule 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Lazaro J. Mandel
    • 1
  • Stephen P. Soltoff
    • 1
  • Peter C. Brazy
    • 1
  1. 1.Department of Physiology and Division of NephrologyDuke University and Durham VA Medical CentersDurhamUSA

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