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Aldosterone Receptors

  • John W. Funder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 196)

Abstract

In 1972, in a collaborative study between the Edelman and Tomkins laboratories, aldosterone was shown to bind two classes of sites in rat kidney preparations.1 Those with higher affinity were proposed as physiological mineralocorticoid Type I receptors, and those with lower affinity for aldosterone Type II, glucocorticoid receptors. The Type I aldosterone binding sites were subsequently shown to have very high affinity for 9α-fluorocortisol and deoxycorticosterone, as well as for aldosterone; moderate affinity for the physiological glucocorticoids cortisol and corticosterone; and relatively low affinity for the synthetic glucocorticoids dexamethasone and triamcinolone acetonide.

Keywords

Mammary Gland Glucocorticoid Receptor Mineralocorticoid Receptor Triamcinolone Acetonide Aldosterone Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John W. Funder
    • 1
  1. 1.Medical Research CentrePrince Henry’s HospitalMelbourneAustralia

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