Cell Interactions in the Ontogeny of the Hemopoietic System

  • Françoise Dieterlen-Lièvre
Part of the NATO ASI Series book series (NSSA, volume 99)


In vivo and in vitro functional tests demonstrate the existence in adult animals of progenitor cells which differentiate into various mature blood cells, provided specific factors are available to them. These progenitors themselves are thought to derive from pluripotent or totipotent stem cells. It is still a major guestionmark whether the differentiating factors determine the commitment of progenitors towards one line of differentiation or whether these factors merely have a trophic action on cells committed through stochastic processes. Whichever the mechanism, the differentiating factors are provided to the progenitors within the microenvironments of hemopoietic organs. Thus functioning of the hemopoietic system is characterized by the interaction of two distinct cell lineages, on one hand the stromal cells which constitute the microenvironments, on the other hand the blood cell progenitors.


Ventral Wall Avian Embryo Differentiate Factor Mature Blood Cell Quail Embryo 
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  1. Dieterlen-Lievre F. and Martin C., 1981, Diffuse intraembryonic hemopoiesis in normal and chimeric avian development, Develop. Biol., 88: 180–191.PubMedCrossRefGoogle Scholar
  2. Jotereau F.V. and Le Douarin N.M., 1982, Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quailthymus during embryonic and perinatal life, J. Immunol., 129: 1869–1877.PubMedGoogle Scholar
  3. Labastie M.C., Thiery J.P. and Le Douarin N.M., 1984, Mouse yolk sac and intraembryonic tissues produce factors able to elicit differentiation of erythroid burst-forming units and colony-forming units, respectively, Proc. Natl. Acad. Sci. USA, 81: 1453–1456.PubMedCrossRefGoogle Scholar
  4. Le Douarin N.M., Dieterlen-Lievre F. and Oliver P., 1984, Ontogeny of primary lymphoid organs and lymphoid stem cells, American J. Anatomy, 170: 261–299.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Françoise Dieterlen-Lièvre
    • 1
    • 2
  1. 1.Institut d’Embryologie du CNRSNogent-sur-MarneFrance
  2. 2.Collège de FranceNogent-sur-MarneFrance

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