Neuronal Migration in the Hippocampal Lamination Defect (Hld) Mutant Mouse

  • Richard S. Nowakowski
Part of the NATO ASI Series book series (NSSA, volume 99)


Movement of cells is an important feature of the development of many tissues and organs in a variety of species (for reviews see Trinkaus, 1976; Abercrombie, 1980). In some cases, cell movement is the result of a passive displacement of the entire tissue including the environment of a cell. In other cases, however, a cell can be considered to migrate in that it actively participates in its displacement and its movement can be considerable relative to the constituents of its environment. This distinction is important because it emphasizes two things. First, a migrating cell generates the forces necessary for locomotion, and it interacts with its environment in order to move through it. Second, the displacement of cells by morphogenetic movements or the growth of a cell without a concomitant displacement of the cell body, e.g., the extension of an axon by a neuron, should not be considered to be cell migration (Weiss, 1961; Carter, 1967; Trinkaus, 1976). During the development of the vertebrate embryo there is a large amount of cell migration both of single cells and populations of cells from one part of the embryo to another. The four best understood examples are: 1) the colonization of the developing gonads by the primordial germ cells, 2) the development of the hematopoietic organs, 3) the extensive migrations of derivatives of the neural crest, and 4) the migration of young neurons in the developing central nervous system.


Dentate Gyrus Neural Crest Pyramidal Cell Neural Crest Cell Mossy Fiber 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Richard S. Nowakowski
    • 1
  1. 1.Department of AnatomyUniversity of Mississipi Medical CenterJacksonUSA

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