Skip to main content

Part of the book series: NATO ASI Series ((NSSA,volume 99))

Abstract

Epithelia are tissues which line or cover the cavities and surfaces of the bodies of animals. They consist of single or stratified sheets of cells which are applied to be underlying tissue on one face, the basal surface, and have a free edge adjacent to a luminal space on the other face, the apical surface. All epithelia thus have a structural apico-basal polarity which is always of great functional importance. For example, in absorptive epithelia such as that of the small intestine, absorption takes place at the apical surface of the cells and the absorbed material is transported basally. In protective epithelia such as the epidermis, the apical surface must be strong in order to resist friction and pressure, while the basal region of the epithelium must generate new cells to replace the stressed apical tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Abercrombie and G.A. Dunn, Exp. Cell Res., 92: 57–62 (1975).

    Article  PubMed  CAS  Google Scholar 

  2. A. Allen, R. Dulbecco, P. Syka and M. Bowman, Proc. Natl. Acad. Sci. USA (in press) (1984).

    Google Scholar 

  3. P.C. Baker and T.E. Schroeder, Dev. Biol., 15: 432 (1967).

    Article  PubMed  CAS  Google Scholar 

  4. H. Bentz, N.P. Morris, L.W. Murray, L.Y. Sakai, D.W. Hollister and R.E. Burgeson, Proc. Natl. Acad. Sci. USA, 80: 3168–3172 (1983).

    Article  CAS  Google Scholar 

  5. D. Billig, A. Nicol, R. McGinty, P. Cowin, J. Morgan and D. Garrod, J. Cell Sci., 57: 51–71 (1982).

    PubMed  CAS  Google Scholar 

  6. J.Z. Borysenko and J.P. Revel, J. Anat., 137: 403–422 (1973).

    Article  CAS  Google Scholar 

  7. A. Bretscher, J. Cell Biol., 97: 425–432 (1983).

    Article  PubMed  CAS  Google Scholar 

  8. R.A. Briggaman and C.E. Wheeler, J. invest. Dermatol., 65: 71–84 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. S.S. Brown, H.L. Malinoff and M.S. Wicha, Proc. Natl. Acad. Sci. USA, 80: 5927–5930 (1983).

    Article  CAS  Google Scholar 

  10. D.R. Burgess, J. Cell Biol., 95: 853–863 (1982).

    Article  PubMed  CAS  Google Scholar 

  11. K. Burridge and P. Mangeat, Nature, 308: 744–746 (1984).

    Article  PubMed  CAS  Google Scholar 

  12. E. Christophers and H.H. Wolf, Nature, 256: 209–210 (1975).

    Article  PubMed  CAS  Google Scholar 

  13. S.M. Cohen, G. Gorbsky and M.S. Steinberg, J. Biol. Chem., 90: 243–248 (1983).

    Google Scholar 

  14. C.A.L.S. Colaco and W.H. Evans, J. Cell Sci., 52: 313–325 (1981).

    PubMed  CAS  Google Scholar 

  15. C.A.L.S. Colaco and W.H. Evans, Electron Microscopy of Proteins, 4: 332–363 (1983).

    Google Scholar 

  16. P. Cowin and D.R. Garrod, Nature, 302: 148–150 (1983).

    Article  PubMed  CAS  Google Scholar 

  17. P. Cowin, D.L. Mattey and D.R. Garrod, J. Cell Sci., 66: 119–132 (1984 a).

    PubMed  CAS  Google Scholar 

  18. P. Cowin, D.L. Mattey and D.R. Garrod, J. Cell Sci., (in press) (1984 b).

    Google Scholar 

  19. S.W. Craig and J.V. Pardo, J. Cell Biol., 80: 203–210 (1979).

    Article  PubMed  CAS  Google Scholar 

  20. A.S.G. Curtis, J. Cell Biol., 20: 199–215 (1964).

    Article  PubMed  CAS  Google Scholar 

  21. C.H. Damsky, J. Richa, D. Solter, K. Knudsen and C.A. Buck, Cell, 34: 455–466 (1983).

    Article  PubMed  CAS  Google Scholar 

  22. H.M. Dembitzer, F. Herz, A. Schermer, R.C. Wooley and L.G. Koss, J. Cell Biol., 85: 695–702 (1980).

    Article  PubMed  CAS  Google Scholar 

  23. R.J. Doherty, J.G. Edwards, D.R. Garrod and D.L. Mattey, J. Cell Sci., (in press) (1984).

    Google Scholar 

  24. P. Drochmans, C. Freudenstein, J.C.Wanson, L. Laurent, T.W. Keenan, J. Stadler, R. Leloup and W. Franke, J. Cell Biol., 80: 231–247 (1978).

    Google Scholar 

  25. T. Ducibella, D.F. Albertini, E. Anderson and J.D. Biggers, Dev. Biol., 45: 231–250 (1975).

    Article  PubMed  CAS  Google Scholar 

  26. R. Dulbecco, W.R. Allen and M. Bowman, Proc. Natl. Acad. Sci. USA, (in press) (1984).

    Google Scholar 

  27. G.M. Edelman, Science, 219: 450–457 (1983).

    Article  PubMed  CAS  Google Scholar 

  28. J.E. Ellison and D.R. Garrod, J. Cell Sci., (in press) (1984).

    Google Scholar 

  29. R.M. Färb, R. Dykes and G.S. Lazarus, Proc. Natl. Acad. Sci. USA, 75: 459–463 (1978).

    Article  Google Scholar 

  30. M.G. Farquhar and G. Palade, J. Cell Biol., 19: 375–412 (1963).

    Article  Google Scholar 

  31. W.W. Franke, H.P. Kaprell and H. Mueller, Eur. J. Cell Biol., 32: 117–130 (1983).

    PubMed  CAS  Google Scholar 

  32. W.W. Franke, R. Moll, D.L. Schiller, E. Schmid, J. Kartenbeck and H. Mueller, Differentiation, 23: 115–127 (1982).

    Article  PubMed  CAS  Google Scholar 

  33. W.W. Franke, E. Schmid, C. Grund, H. Mueller, I. Engelbrecht, R. Moll, J. Stadler and E.D. Jarasch, Differentiation, 20: 217–241 (1981).

    Article  PubMed  CAS  Google Scholar 

  34. D.R. Garrod, Fortschritter der Zoologie, 26: 184–195 (1981).

    Google Scholar 

  35. D.R. Garrod and P. Cowin, In: “Receptors in Tumour Biology”, ed. C.M. Chadwick (in press) (1984).

    Google Scholar 

  36. D.R. Garrod and A. Nicol, Biol. Rev., 56: 199–242 (1981).

    Article  PubMed  CAS  Google Scholar 

  37. B. Geiger, A.H. Dutton, K.T. Tokuyasu and S.J. Singer, J. Cell Biol., 91: 614–628 (1981).

    Article  PubMed  CAS  Google Scholar 

  38. B. Geiger, E. Schmid and W.W. Franke, Differentiation, 23: 189–205 (1983).

    Article  PubMed  CAS  Google Scholar 

  39. B. Geiger, K.T. Tokuyasu, A.H. Dutton and S.J. Singer, Proc. Natl. Acad. Sci. USA, 77: 4127–4131 (1980).

    Article  CAS  Google Scholar 

  40. B.M. Geiger, K.T. Tokuyasu and S.J. Singer, Proc. Natl. Acad. Sci. USA, 76: 2833–2837 (1979).

    Article  CAS  Google Scholar 

  41. N.B. Gilula, In: “Intercellular Junctions and Synapses”, ed. J. Feldman, N.B. Gilula and J.D. Pitts, ( Chapman and Hall, London ), pp. 1–22 (1978).

    Google Scholar 

  42. I.K. Gipson, M.S. Grill, S.J. Spurr and S.J. Brennan, J. Cell Biol., 97: 849–857 (1983).

    Article  PubMed  CAS  Google Scholar 

  43. G. Gorbsky, S. Cohen and M.S. Steinberg, J. invest. Dermatol., 80: 475–480 (1983).

    Article  PubMed  CAS  Google Scholar 

  44. G. Gorbsky and M.S. Steinberg, J. Cell Biol., 90: 243–248 (1981).

    Article  PubMed  CAS  Google Scholar 

  45. H. Green, O. Kehinde and J. Thomas, Proc. Natl. Acad. Sci. USA, 76: 5665–5668 (1979).

    Article  CAS  Google Scholar 

  46. J.P. Heath, In: “Cell Behaviour”, ed. R. Bellairs, A.S.G. Curtis and G.A. Dunn, ( Cambridge University Press ), pp. 77–108 (1982).

    Google Scholar 

  47. J.P. Heath and G.A. Dunn, J. Cell Sci., 29: 197–212 (1978).

    PubMed  CAS  Google Scholar 

  48. D. Henderson and K. Weber, Exp. Cell Res., 132: 297–311 (1981).

    Article  PubMed  CAS  Google Scholar 

  49. H. Hennings and K. Holbrook, Exp. Cell Res., 143: 127–142 (1983).

    Article  PubMed  CAS  Google Scholar 

  50. H. Hennings, K.A. Holbrook and S.H. Yuspa, J. Cell Physiol., 116: 265–281 (1983 a).

    Article  PubMed  CAS  Google Scholar 

  51. H. Hennings, K.A. Holbrook and S.H. Yuspa, J. invest. Dermatol., 81: 50s–55s (1983 b).

    Article  Google Scholar 

  52. H. Hennings, D. Michael, C. Cheng, P. Steinert, K. Holbrook and S.H. Yuspa, Cell, 19: 245–254 (1980).

    Article  PubMed  CAS  Google Scholar 

  53. D.A. Herzlinger and G.K. Ojakian, J. Cell Biol., 98: 1777–1787 (1984).

    Article  PubMed  CAS  Google Scholar 

  54. C.S. Izzard and L.R. Lochner, J. Cell Sci., 21: 129–159 (1976).

    PubMed  CAS  Google Scholar 

  55. M.A. Jakus, Invest. Ophtalmol., 1: 202–225 (1962).

    CAS  Google Scholar 

  56. J.C.R. Jones, J. Arun, L.A. Staehelin and R.D. Goldman, Proc. Natl. Acad. Sci. USA, 81: 2781–2785 (1984).

    Article  PubMed  CAS  Google Scholar 

  57. P. Karfunkel, Dev. Biol., 25: 30 (1971).

    Article  PubMed  CAS  Google Scholar 

  58. J. Kartenbeck, W.W. Franke, J.G. Moser and U. Stoffels, EMBO J, 2: 735–742 (1983).

    PubMed  CAS  Google Scholar 

  59. J. Kartenbeck, E. Schmid, W.W. Franke and B. Geiger, EMBO J., 1: 725–732 (1982).

    PubMed  CAS  Google Scholar 

  60. J. Kartenbeck, K. Schwechleimer, R. Moll and W.W. Franke, J. Cell Biol., 98: 1072–1081 (1984).

    Article  PubMed  CAS  Google Scholar 

  61. D.E. Kelly, J. Cell Biol., 28: 51–73 (1966).

    Article  PubMed  CAS  Google Scholar 

  62. M.W. Klymkowsky, R.H. Miller and E.B. Lane, J. Cell Biol., 96: 494–509 (1983).

    Article  PubMed  CAS  Google Scholar 

  63. W.S. Krawczyk and G.F. Wilgram, J. Ultrastruct. Res., 45: 93–101 (1973).

    Article  PubMed  CAS  Google Scholar 

  64. E.B. Lane, J. Cell Biol., 92: 665–673 (1982).

    Article  PubMed  CAS  Google Scholar 

  65. N.J. Lane, In: “Electron Microscopy” Vol. 3, State of the Art Symposia ed. J.M. Sturgess, (Imperial Press, Toronto), pp. 673–691 (1978).

    Google Scholar 

  66. T.L. Lentz and J.P. Trinkaus, J. Cell Biol., 48: 455–472 (1971).

    Article  PubMed  CAS  Google Scholar 

  67. H.L. Malinoff and M.S. Wicha, J. Cell Biol., 96: 1475–1479 (1983).

    Article  PubMed  CAS  Google Scholar 

  68. D.L. Mattey and D.R. Garrod, J. Cell Sci., 67: 171–188 (1984a).

    PubMed  CAS  Google Scholar 

  69. D.L. Mattey and D.R. Garrod, J. Cell Sci., 67: 189–202 (1984b).

    PubMed  CAS  Google Scholar 

  70. D.L. Mattey and D.R. Garrod, in preparation, (1984 c).

    Google Scholar 

  71. N.S. McNutt and R.S. Weinstein, Prog. Biophys. Mol. Biol., 26: 45–101 (1976).

    Article  Google Scholar 

  72. J. Mollenhauer and K. von der Mark, EMBO J., 2: 45–50 (1983).

    PubMed  CAS  Google Scholar 

  73. J. Morgan and D.R. Garrod, J. Cell Sci., 66: 133–145 (1984).

    PubMed  CAS  Google Scholar 

  74. H. Mueller and W.W. Franke, J. mol. Biol., 163: 647–671 (1983).

    Article  PubMed  CAS  Google Scholar 

  75. A. Nicol and D.R. Garrod, J. Cell Sci., 54: 357–372 (1982).

    PubMed  CAS  Google Scholar 

  76. C. Ocklind, U. Forsum and D. Obrink, J. Cell Biol., 96: 1168–1171 (1983).

    Article  PubMed  CAS  Google Scholar 

  77. B. Oesch and W. Birchmeier, Cell, 31: 671–679 (1982).

    Article  PubMed  CAS  Google Scholar 

  78. S.I. Ogou, G. Yoshida-Noro and M. Takeichi, J. Cell Biol., 97: 944–948 (1983).

    Article  PubMed  CAS  Google Scholar 

  79. J. Overton, J. exp. Zool., 168: 203–214 (1968).

    Article  PubMed  CAS  Google Scholar 

  80. J. Overton, Prog. Surf. Sci., 8: 161–208 (1974).

    Google Scholar 

  81. J. Overton, Dev. Biol., 55: 103–116 (1977).

    Article  PubMed  CAS  Google Scholar 

  82. G.E. Palade and M.G. Farquhar, J. Cell Biol., 27: 215–224 (1965).

    Article  PubMed  CAS  Google Scholar 

  83. N.C. Rao, S.H. Barsky, V.P. Terranova and L.A. Liotta, Biochem. Biophys. Res. Commun., 111: 804–808 (1983).

    Article  CAS  Google Scholar 

  84. D.G. Rayns, F.O. Simpson and J.M. Ledingham, J. Cell Biol., 42: 322–326 (1969).

    Article  PubMed  CAS  Google Scholar 

  85. D.A. Rees, R.A. Badley, C.E. Lloyd, D. Thomn and C.G. Smith, In: “Cell-cell Recognition” 32 nd. Symp. Soc. Exp. Biol. ed. A.S.G. Curtis, (Cambridge University Press, Cambridge), pp. 241–260 (1978).

    Google Scholar 

  86. L.A. Represh and J.C. Oberpriller, Am. J. Anat., 159: 187–208 (1980).

    Article  Google Scholar 

  87. J.G. Rheinwald and H. Green, Cell, 6: 331–344 (1975).

    Article  PubMed  CAS  Google Scholar 

  88. K. Rubin, M. Hook, B. Obrink and R. Timpl, Cell, 24: 463–470 (1981).

    Article  PubMed  CAS  Google Scholar 

  89. I.I. Singer, J. Cell Biol., 92: 398–408 (1982).

    Article  PubMed  CAS  Google Scholar 

  90. C.J. Skerrow and G.A. Matoltsy, J. Cell Biol., 63: 515–523 (1974).

    Article  PubMed  CAS  Google Scholar 

  91. L.A. Staehelin, Int. Rev. Cytol., 39: 191–283 (1974).

    Article  PubMed  CAS  Google Scholar 

  92. M.S. Steinberg, In: “Cellular Membranes in Development” ed. M. Locke, ( Academic Press, New-York ), pp. 321–366 (1964).

    Google Scholar 

  93. M.S. Steinberg, J. Exp. Zool., 173: 395–434 (1970).

    Article  PubMed  CAS  Google Scholar 

  94. M.S. Steinberg, In: “Specificity of Embryological Interactions” ed. D.R. Garrod, (Chapman and Hall, London), pp. 99–130 (1978 a).

    Google Scholar 

  95. M.S. Steinberg, In: “Cell-cell Recognition” 32 nd Symp. Soc. Exp. Biol. ed. A.S.G. Curtis, (Cambridge University Press, Cambridge), pp. 25–49 (1978 b).

    Google Scholar 

  96. M. Stoker, J. Cell Physiol., (in press) (1984).

    Google Scholar 

  97. S.P. Sugrue and E.D. Hay, Dev. Biol., 92: 97–106 (1982).

    Article  PubMed  CAS  Google Scholar 

  98. A. Suhrbier and D.R. Garrod, in preparation, (1984).

    Google Scholar 

  99. L.G. Tilney and M.S. Mooseker, Proc. Natl. Acad. Sci. USA, 68: 2611–2615 (1971).

    Article  CAS  Google Scholar 

  100. V. Trinkaus-Randall and I.K.Gipson, J. Cell Biol., 98: 1565–1571 (1984).

    Article  PubMed  CAS  Google Scholar 

  101. F.M. Watt and H. Green, Nature, 295: 434–436 (1982).

    Article  PubMed  CAS  Google Scholar 

  102. F.M. Watt, D.M. Mattey and D.R. Garrod, J. Cell Biol., (in press) (1984).

    Google Scholar 

  103. R.S. Weinstein, F.B. Merk and J. Al’roy, Adv. Cancer Res., 23: 23–89 (1976).

    Article  PubMed  CAS  Google Scholar 

  104. L.L. Wiseman and J. Strickler, J. Cell Sci., 49: 217–224 (1981).

    PubMed  CAS  Google Scholar 

  105. A. Woods, M. Hook, L. Kjellen, C.G. Smith and D.A. Rees, J. Cell Biol., (in press) (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Garrod, D.R. (1985). The Adhesions of Epithelial Cells. In: Marthy, HJ. (eds) Cellular and Molecular Control of Direct Cell Interactions. NATO ASI Series, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5092-7_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5092-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5094-1

  • Online ISBN: 978-1-4684-5092-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics