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Junctional Communication and Communication Compartments in Development

  • John D. Pitts
  • Malcolm E. Finbow
  • T. Eldridge
  • J. Buultjens
  • Ephraim Kam
  • John Shuttleworth
Part of the NATO ASI Series book series (NSSA, volume 99)

Abstract

Two quite different lines of research led to independent discoveries of junctional communication between animal cells. Neurophysiologists interested in the interactions between nerve cells showed the presence at some sites of low resistance pathways or junctions which allow the direct movement of current carrying ions between the cytoplasms of adjacent cells (1). This work was extended in two important ways to show first that these low resistance junctions are also present (and much more frequently) between cells in non-excitable tissues (2, 3), and second that certain small molecular weight fluorescent dyes could also pass through the intercellular junctions (2, 3). Since these early observations, electrical coupling and dye coupling have been extensively used to define the nature and roles of the junctional pathway and these studies are described in other chapters of this book.

Keywords

Cumulus Cell Intercellular Junction Purine Nucleotide Junctional Communication Proliferative Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John D. Pitts
    • 1
  • Malcolm E. Finbow
    • 1
  • T. Eldridge
    • 1
  • J. Buultjens
    • 1
  • Ephraim Kam
    • 1
  • John Shuttleworth
    • 1
  1. 1.The Beatson Institute for Cancer ResearchGarscube EstateGlasgowScotland

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