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Cell Surface Components and Differentiation in Neuroblastoma Culture

  • Gabriella Augusti-Tocco
Part of the NATO ASI Series book series (NSSA, volume 99)

Abstract

In the development of the nervous system, cells are committed to become neurons and glial cells well before any sign of cellular differentiation is apparent. Cytodifferentiation is a complex process which occurs gradually and progressively restricts the developmental potentialities of the stem cells. Successive stages of neuron cytodifferentiation have been indicated as germinal cells, neuroblasts and neurons. As cells progress through these stages many cellular and molecular events occur, such as:
  1. restriction

    of mitotic activity,

     
  2. increase

    of cell size,

     
  3. acquisition

    of typical cell shape, characterized by fiber formation,

     
  4. acquisition

    of action potential mechanism,

     
  5. appearance

    of neurotransmitter synthesizing enzymes and mechanism of neurotransmitter storage and release,

     
  6. appearance

    of specific receptors,

     
  7. formation

    of synaptic contacts with target cells.

     

Keywords

Dorsal Root Ganglion Neuroblastoma Cell Heparan Sulphate Hybrid Cell Undifferentiated Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Gabriella Augusti-Tocco
    • 1
  1. 1.Dipartimento di Biologia Cellulare e dello SviluppoUniversita di Roma “La Sapienza” Piazzale A. MoroRomaItaly

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