Advertisement

Acetylcholine Receptor Clustering and the Formation of the Neuromuscular Junction

  • Robert J. Bloch
  • David W. Pumplin
  • Manfred Baetscher
Part of the NATO ASI Series book series (NSSA, volume 99)

Abstract

The molecular mechanisms involved in the formation of the nervous system are not yet understood, and experimental approaches to study them are not easy to come by. Several problems face the researcher in this area. For example, in any particular part of the brain there are several different types of neurons, which are difficult to distinguish while alive. These neurons are involved in several different types of synapses, utilizing different neurotransmitters and neurotransmitter receptors. Molecular markers for the different cell types and for their pre- and postsynaptic connections are useful only for autoradiographic studies of whole brain slices. Without markers for use at the cellular level, a detailed description of the assembly of synapses and neuronal circuits will not be possible.

Keywords

Neuromuscular Junction AChR Cluster Contact Domain Microfilament Bundle Saponin Extraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D.M. Fambrough, Physiol. Rev., 59: 165–227 (1979).PubMedGoogle Scholar
  2. 2.
    C. Edwards, Neurosci., 4: 565–584 (1979).CrossRefGoogle Scholar
  3. 3.
    J.R. Sanes, Ann. Rev. Physiol., 45: 581–600 (1983).CrossRefGoogle Scholar
  4. 4.
    R.J. Bloch and J.H. Steinbach, In: “Receptors in cellular recognition and developmental processes”, ed. R.M. Gorczynski, Academic Press, in the press (1985).Google Scholar
  5. 5.
    M.J. Dennis, L. Ziskind-Conhaim and A.J. Harris, Dev. Biol., 81: 266–279 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    J. Matthews-Bellinger and M.M. Salpeter, J. Neurosci., 3: 644–657 (1983).PubMedGoogle Scholar
  7. 7.
    J.H. Steinbach, Dev. Biol., 84: 267–276 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    C.R. Slater, Dev. Biol., 94: 11–22 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    D. Axelrod, P. Ravdin, D.E. Koppel, J. Schlessinger, W.W. Webb, E.L. Elson and T.R. Podleski, Proc. Natl. Acad. Sci. USA, 73: 4594–4598 (1976).PubMedCrossRefGoogle Scholar
  10. 10.
    C.G. Reiness and C.B. Weinberg, Dev. Biol., 84: 247–254 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    M.M. Salpeter, S. Spanton, K. Holley and T.R. Podleski, J. Cell Biol., 93: 417–425 (1982).PubMedCrossRefGoogle Scholar
  12. 12.
    R.J. Bloch, J. Cell Biol., 82: 626–643 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    R.J. Bloch, J. Neurosci., 3: 2670–2680 (1983).PubMedGoogle Scholar
  14. 14.
    R.J. Bloch and J.H. Steinbach, Dev. Biol., 81: 386–391 (1981).PubMedCrossRefGoogle Scholar
  15. 15.
    G.D. Fischbach and S.M. Schuetze, J. Physiol., 303: 125–137 (1980).PubMedGoogle Scholar
  16. 16.
    C.G. Reiness and Z.W. Hall, Dev. Biol., 81: 324–331 (1981).PubMedCrossRefGoogle Scholar
  17. 17.
    R.J. Bloch and B. Geiger, Cell, 21: 25–35 (1980).PubMedCrossRefGoogle Scholar
  18. 18.
    J.M. Anderson, M.W. Cohen and E. Zorychta, J. Physiol., 268: 731–756 (1977).PubMedGoogle Scholar
  19. 19.
    J.M. Anderson and M.W. Cohen, J. Physiol., 268: 757–773 (1977).PubMedGoogle Scholar
  20. 20.
    L. Ziskind-Conhaim, I. Geffen and Z.W. Hall, J. Neurosci., 4: 2346–2349 (1984).PubMedGoogle Scholar
  21. 21.
    S. Bursztajn, S.A. Berman, J. McManaman and S.H. Appel, Abst. Soc. Neurosci., 9: 1059 (1982).Google Scholar
  22. 22.
    J.A. Connolly, J. Cell Biol., 99: 148–154 (1984).PubMedCrossRefGoogle Scholar
  23. 23.
    C. Kalcheim, Z. Vogel and D. Duksin, Proc. Natl. Acad. Sci. USA, 79: 3077–3081 (1982).PubMedCrossRefGoogle Scholar
  24. 24.
    C. Kalcheim, D. Duksin and Z. Vogel, J. Biol. Chem., 257: 12722–12727 (1982).PubMedGoogle Scholar
  25. 25.
    R.M. Nitkin, B.G. Wallace, M.E. Spira, E.W. Godfrey and U.J. McMahan, Cold Spring Harbor Symp. Quant. Biol., 48: 653–665 (1983).CrossRefGoogle Scholar
  26. 26.
    Z.W. Hall, B.W. Lubit and J.H. Schwartz, J. Cell Biol., 90: 789–792 (1981).PubMedCrossRefGoogle Scholar
  27. 27.
    R.J. Bloch and W.G. Resneck, Abst. Soc. Neurosci., 9: 757 (1983).Google Scholar
  28. 28.
    R.J. Bloch and Z.W. Hall, J. Cell Biol., 97: 217–223 (1983).PubMedCrossRefGoogle Scholar
  29. 29.
    R.J. Bloch, unpublished results.Google Scholar
  30. 30.
    S. Burden, J. Cell Biol., 94: 521–530 (1982).PubMedCrossRefGoogle Scholar
  31. 31.
    S. Froehner, J. Cell Biol., 99: 88–96 (1984).PubMedCrossRefGoogle Scholar
  32. 32.
    M.J. Anderson and D.M. Farabrough, J. Cell Biol., 97: 1396–1411 (1983).PubMedCrossRefGoogle Scholar
  33. 33.
    F. Moody-Corbett and M.W. Cohen, J. Neurosci., 1: 596–605 (1981).PubMedGoogle Scholar
  34. 34.
    M.M. Salpeter, 32: 379–389 (1967).Google Scholar
  35. 35.
    J.R. Sanes, J. Cell Biol., 93: 442–451 (1982).PubMedCrossRefGoogle Scholar
  36. 36.
    Z. Vogel, C.N. Christian, M. Vigny, H.C. Bauer, P. Sonderegger and M.P. Daniels, J. Neurosci., 1058–1068 (1983).Google Scholar
  37. 37.
    E.K. Bayne, M.J. Anderson and D.M. Fambrough, J. Cell Biol., 99: 1486–1501 (1984).PubMedCrossRefGoogle Scholar
  38. 38.
    C.N. Christian, M.P. Daniels, H. Sugiyama, L. Jacques and P.G. Nelson, Proc. Natl. Acad. Sci. USA, 75: 4011–4014 (1978).PubMedCrossRefGoogle Scholar
  39. 39.
    M.H. Buc-Caron, P. Nystrom and G.F. Fischbach, Dev. Biol., 95: 378–386 (1983).PubMedCrossRefGoogle Scholar
  40. 40.
    T.R. Podleski, D. Axelrod, P. Ravdin, I. Greenberg, M.M. Johnson and M.M. Salpeter, Proc. Natl. Acad. Sci. USA, 75: 2035–2039 (1978).PubMedCrossRefGoogle Scholar
  41. 41.
    D. Axelrod, J. Cell Biol., 89: 141–145 (1981).PubMedCrossRefGoogle Scholar
  42. 42.
    H.B. Peng and K.A. Phelan, J. Cell Biol., 99: 344–349 (1984).PubMedCrossRefGoogle Scholar
  43. 43.
    S.J. Burden, P.B. Sargeant and U.J. McMahan, J. Cell Biol., 82: 412–425 (1979).PubMedCrossRefGoogle Scholar
  44. 44.
    T.G. Burrage and T.L. Lentz, Dev. Biol., 85: 267–286 (1981).PubMedCrossRefGoogle Scholar
  45. 45.
    U.J. McMahan and C.R. Slater, J. Cell Biol., 98: 1453–1473 (1984).PubMedCrossRefGoogle Scholar
  46. 46.
    B. Geiger, Cell, 18: 193–205 (1979).PubMedCrossRefGoogle Scholar
  47. 47.
    D.W. Pumplin and R.J. Bloch, J. cell Biol., 97: 1043–1054 (1983).PubMedCrossRefGoogle Scholar
  48. 48.
    R.J. Bloch, J. Cell Biol., 99: 984–993 (1984).PubMedCrossRefGoogle Scholar
  49. 49.
    J. Boyles and D.F. Bainton, J. Cell Biol., 82: 347–368 (1979).PubMedCrossRefGoogle Scholar
  50. 50.
    C. Ocklind, U. Forsum and B. Obrink, J. Cell Biol., 96: 1168–1171 (1983).PubMedCrossRefGoogle Scholar
  51. 51.
    I.I. Singer, J. Cell Biol., 92: 398–408 (1982).PubMedCrossRefGoogle Scholar
  52. 52.
    K. Burridge and J.R. Feramisco, Cell, 19: 587–595 (1980).PubMedCrossRefGoogle Scholar
  53. 53.
    J.A. Weatherbee, Int. Rev. Cytol. Suppl., 12: 113–176 (1981).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Robert J. Bloch
    • 1
  • David W. Pumplin
    • 2
  • Manfred Baetscher
    • 1
  1. 1.Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of AnatomyUniversity of Maryland School of MedicineBaltimoreUSA

Personalised recommendations