Catecholamine Metabolism and Digital Circulation after Histamine and Its Analogue

Krypton Clearance and Calorimetric Blood Flow
  • Nosrat Eric Naftchi
  • Milton Mendlowitz
  • Stefan Racoceanu
  • Edward W. Lowman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


In 1959 (1) we reported the paradoxical effects on the digital circulation of histamine administered parenterally and of an orally ingested histamine analogue* (2). Both histamine and its analogue produced vasodilatation of the capillaries as manifested by flushing contrasted with vasoconstriction of the arteriovenous anastomoses (AVAS). It was postulated at that time that the AVA constricted in response to heat loss produced by histamine-mediated precapillary sphincter and hence capillary vasodilatation. The question as to whether the AVA constriction was a neural reflex or produced by some other mechanism such as the release of catecholamines (CM) from nerve endings and/or chrcmaff in tissues remained unanswered (3).


Ulnar Nerve Mandelic Acid Disappearance Rate Capillary Blood Flow Lidocaine Hydrochloride 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Nosrat Eric Naftchi
    • 1
  • Milton Mendlowitz
    • 2
  • Stefan Racoceanu
    • 2
  • Edward W. Lowman
    • 1
  1. 1.Laboratory of Biochemical Pharmacology, Institute of Rehabilitation MedicineNew York University Medical CenterNew YorkUSA
  2. 2.The Department of Medicine, The Mount Sinai School of MedicineThe City University of New YorkUSA

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