Catecholamine Metabolism and Digital Circulation after Histamine and Its Analogue
In 1959 (1) we reported the paradoxical effects on the digital circulation of histamine administered parenterally and of an orally ingested histamine analogue* (2). Both histamine and its analogue produced vasodilatation of the capillaries as manifested by flushing contrasted with vasoconstriction of the arteriovenous anastomoses (AVAS). It was postulated at that time that the AVA constricted in response to heat loss produced by histamine-mediated precapillary sphincter and hence capillary vasodilatation. The question as to whether the AVA constriction was a neural reflex or produced by some other mechanism such as the release of catecholamines (CM) from nerve endings and/or chrcmaff in tissues remained unanswered (3).
KeywordsUlnar Nerve Mandelic Acid Disappearance Rate Capillary Blood Flow Lidocaine Hydrochloride
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- 3.Naftchi, N.E. and Mendlowitz, M.: Mechanism of paradoxical effect of histamine and its analogue on capillaries and arteriovenous anastcmoses of the human digit. Fed. Proc. 26:785, 1967 (abstract).Google Scholar
- 6.Mendlowitz, M., Naftchi, N.E. and Wolf, R.L.: The effect of trimethaphan camphorsulfonate on the human digital circulation. Clin. Pharm. and Ther. 9:1, 1968.Google Scholar
- 7.Mendlowitz, M.: The digital circulation. Grune and Stratton, New York, 1954.Google Scholar
- 9.Relier, C., Sheridan, J. and Aust, J.B.: Capillary blood flow determination with Kr85. Fed. Proc. 24:443, 1965.Google Scholar
- 14.Dale, H.H. and Laidlaw, P.P.: The physiological action of -imidazolethylamine, J. Physiol. Lon. 41:318, 1910.Google Scholar
- 15.Dale, H.H.: Some chemical factors in the control of the circulation. Lancet 1:1179, 1233, 1285, 1929.Google Scholar
- 17.Douglas, W.W., Kanno, T. and Sampson, S.R.: Effects of acetylcholine and other medullary secretagogues and antagonists on the membrane potential of adrenal chromaffin cells. J. Physiol., London 188: 107, 1967.Google Scholar
- 18.Staszewska-Barczak, J. and Vane, J.R.: The release of catecholamines from the adrenal medulla by histamine. Br. J. Pharm. Chemother. 25:728, 1965.Google Scholar
- 19.Axelrod, J., Maclean, P.D. and Wayne Albers, R., Wiessbach, H.: Regional neurochemistry. Pergamon Press, London, 307, 1961.Google Scholar
- 20.Douglas, W.W.: Histamine and antihistamines: 5-hydroxytryptamine and antagonists. In: The Pharmacological Basis of Therapeutics, edited by Goodman, L.S. and Gilman, A. London, The Macmillan Company, 1970, P.621.Google Scholar
- 21.Kakiuchi, S. and Rail, T.W.: The influence of chemical agents on the accumulation of adenosine 3′, 5′-phosphate in slices of rabbit cerebellum. Mol. Pharmacol. 4:367, 1968a.Google Scholar
- 22.Kakiuchi, S. and Rall, T.W.: Studies on adenosine 3′,5′-phosphate in rabbit cerebral cortex. Mol. Pharmacol. 4: 379, 1968b.Google Scholar