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Pharmacological Stimulation of Red Blood Cell Metabolism for High Altitude Preadaptation

  • Lorna Grindlay Moore
  • George J. Brewer
  • Fred J. OelshlegelJr.
  • Andrew M. Rose
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

A decrease in erythrocyte oxygen affinity is held to be an important component of high altitude adaptation. Ordinarily at 10–11,000 feet, a four to five day period or longer of exposure to high altitude is required to build-up the 2,3-diphosphoglyccrate (DPG) levels of red cells which brings about the decrease in oxygen affinity. It is during this early period of altitude exposure that symptoms (acute mountain sickness) related chiefly to the central nervous system are frequently experienced.

Keywords

Phosphate Solution Acute Mountain Sickness Oxygen Affinity Pharmacological Stimulation Altitude Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References Cited

  1. Brain, M.C. and Card, R.T. (1972). In “Hemoglobin and Red Cell Structure and Function” (G.J. Brewer, ed.), Advances in Experimental Medicine and Biology, Vol. 28, pp. 145–154. Plenum Press, New York.CrossRefGoogle Scholar
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  3. Moore, L.G., Brewer, G.J., and Oelshlegel, F.J., Jr. (1972). In “Hemoglobin and Red Cell Structure and Function” (G.J. Brewer, ed.), Advances in Experimental Medicine and Biology, Vol. 28, pp. 397–413- Plenum Press, New York.CrossRefGoogle Scholar
  4. Rapoport, S. (1968). In “Essays in Biochemistry” (P.N. Campbell and G.D. Greville, eds.), Vol. 4, pp. 69–103. Academic Press, New York.Google Scholar
  5. Rose, I.A., Warms, J.V., and O’Connell, E.L. (1964). Biochem. Biophys. Research Communs. 15, 33.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Lorna Grindlay Moore
    • 1
  • George J. Brewer
    • 1
  • Fred J. OelshlegelJr.
    • 1
  • Andrew M. Rose
    • 1
  1. 1.Departments of Anthropology, Human Genetics, and Human Performance CenterUniversity of MichiganAnn ArborUSA

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