Pharmacological Stimulation of Red Blood Cell Metabolism for High Altitude Preadaptation
A decrease in erythrocyte oxygen affinity is held to be an important component of high altitude adaptation. Ordinarily at 10–11,000 feet, a four to five day period or longer of exposure to high altitude is required to build-up the 2,3-diphosphoglyccrate (DPG) levels of red cells which brings about the decrease in oxygen affinity. It is during this early period of altitude exposure that symptoms (acute mountain sickness) related chiefly to the central nervous system are frequently experienced.
KeywordsPhosphate Solution Acute Mountain Sickness Oxygen Affinity Pharmacological Stimulation Altitude Exposure
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