Hemoglobin Concentration Overestimates Oxygen Carrying Capacity during Favic Crises
Acute hemolytic anemia in patients with red blood cells deficient in enzymes such as G-6-PD is characterized by excessive oxidation of hemoglobin (Hgb) to a variety of soluble heme pigments and to precipitates, known as Heinz bodies, attached to the inner coat of the red cell membrane. These pigments and precipitates do not carry oxygen. The cyanmethemoglobin method, widely used to determine blood Hgb concentration, detects not only Hgb but methemoglobin and other non-oxygen carrying heme pigments as well. In a previous study (P. M. Taylor, et al., Proc. Soc. Exper. Biol. Med., in press) we tested the hypothesis that non-oxygen carrying pigments might constitute a significant fraction of “hemoglobin,” as measured by the cyanmethemoglobin method, during the course of acute hemolytic anemia induced in dogs by Phenylhydrazine, a potent oxidizing agent.
KeywordsIron Deficiency Anemia Oxygen Carry Capacity Blood Hemoglobin Concentration Heinz Body Fava Bean
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