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Hemoglobin Concentration Overestimates Oxygen Carrying Capacity during Favic Crises

  • P. M. Taylor
  • L. G. Morphis
  • K. Mandalenaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

Acute hemolytic anemia in patients with red blood cells deficient in enzymes such as G-6-PD is characterized by excessive oxidation of hemoglobin (Hgb) to a variety of soluble heme pigments and to precipitates, known as Heinz bodies, attached to the inner coat of the red cell membrane. These pigments and precipitates do not carry oxygen. The cyanmethemoglobin method, widely used to determine blood Hgb concentration, detects not only Hgb but methemoglobin and other non-oxygen carrying heme pigments as well. In a previous study (P. M. Taylor, et al., Proc. Soc. Exper. Biol. Med., in press) we tested the hypothesis that non-oxygen carrying pigments might constitute a significant fraction of “hemoglobin,” as measured by the cyanmethemoglobin method, during the course of acute hemolytic anemia induced in dogs by Phenylhydrazine, a potent oxidizing agent.

Keywords

Iron Deficiency Anemia Oxygen Carry Capacity Blood Hemoglobin Concentration Heinz Body Fava Bean 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • P. M. Taylor
    • 1
    • 2
  • L. G. Morphis
    • 1
    • 2
  • K. Mandalenaki
    • 1
    • 2
  1. 1.Depts. of Ped.Univ. of Pittsburgh Sch. of Med.AthensGreece
  2. 2.St. Sophia Hosp.Athens Univ. Med. Sch.AthensGreece

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