Oxygen Transport and Tissue Oxygenation During Hemodilution with Dextran

  • K. Meßmer
  • L. Görnandt
  • F. Jesch
  • E. Sinagowitz
  • L. Sunder-Plassmann
  • M. Kessler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

The major problem in volume replacement therapy using erythrocyte free solutions is the maintenance of adequate oxygen supply to the tissues. Inspite of the wide spread use of dextran solutions the effects on oxygen transport and oxygen supply to the tissues are still not fully understood. The aim of this paper is therefore to present conclusive evidence about the effects of dextran on tissue oxygenation, discussing not only its effects on the macrohemodynamics and microcirculatory flow but discussing as well its influence on the respiratory function of the blood.

Keywords

Platinum Anemia Dextran Dial Compro 

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References

  1. 1.
    Duvelleroy, M.A., Buckles, R.G., Rosenkaimer, S., Tung, C. and Laver, M.B. J. appl.Physiol. 28:227 (1970).PubMedGoogle Scholar
  2. 2.
    Hint, H. Acta Anaesth. Belg. 19:119 (1968).PubMedGoogle Scholar
  3. 3.
    Kessler, M., Grunewald, W. Progr.Resp.Res. 3:147–152 (Karger, Basel/New York, 1969).Google Scholar
  4. 4.
    Knorpp, K., Bauer, Ch., Rathschlag-Schaefer, A.M., Bartels, H. Arzneimittelforschung (Drug Research) 20:853 (1970).Google Scholar
  5. 5.
    Kunze, K., Significance of oxygen pressure field measurements in human muscle with special remarks on PCL micro-neelde electrodes. In: Oxygen pressure recording in gases, fluids and tissues. Eds.: F. Kreuzer and H. Herzog, pp. 153–157, Basel/New York, Karger (1969).Google Scholar
  6. 6.
    Meßmer, K., Lewis, D.H., Sunder-Plassmann, L., Kloevekorn, W.P., Mendier, N. and Holper, K. Europ.Surg.Res. 4:55 (1972).CrossRefGoogle Scholar
  7. 7.
    Meßmer, K., Schmid-Schönbein, H.(Ed.) Hemodilution: Theoretical basis and clinical application. Basel/New York, Karger (1972).Google Scholar
  8. 8.
    Meßmer, K., Sunder-Plassmann, L., Klovekorn, W.P., Holper, K. Adv. Microcirc. 4:1–70 (1972).Google Scholar
  9. 9.
    Meßmer, K., Sunder-Plassmann, L., Jesch, F., Görnandt, L., Sinagowitz, E. and Kessler, M. Res.exp.Med. 159:152 (1973).CrossRefGoogle Scholar
  10. 10.
    Murray, J.P., Escobar, E., Rappaport, E. Amer.J.Physiol. 216:638 (1969).PubMedGoogle Scholar
  11. 11.
    Replogle, R. Hemodynamic compensation of acute changes of the hemoglobin concentration, p. 160. In: Meßmer, K., Schmid-Schönbein, H.: Hemodilution theoretical basis and clinical application, Basel/New York, Karger (1972).Google Scholar
  12. 12.
    Sunder-Plassmann, L., Klövekorn, W.P., Holper, K., Hase, U., Meßmer, K. The physiological significance of acutely induced hemodilution. In: Ditzel/Lewis: Proc.6th Europ.Conf.Microcirculation, Aalborg 1970, p. 23–28, Basel/New York, Karger (1971).Google Scholar
  13. 13.
    Veragat, U.P., Krayenbühl, H.P. Cardiologia 47:96 (1965).CrossRefGoogle Scholar
  14. 14.
    Versmold, H., Olbrich, G., Hollmann, E., Riegel, K. Klin.Paediat. 1973 (in press).Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • K. Meßmer
    • 1
    • 2
  • L. Görnandt
    • 1
    • 2
  • F. Jesch
    • 1
    • 2
  • E. Sinagowitz
    • 1
    • 2
  • L. Sunder-Plassmann
    • 1
    • 2
  • M. Kessler
    • 1
    • 2
  1. 1.Institut f. Surgical ResearchUniversity MunichW.Germany
  2. 2.Max-Planck-Inst. Applied PhysiologyDortmundW.Germany

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