Threshold Values of Oxygen Deficiency Leading to Cardiovascular and Brain Pathological Changes in Term Monkey Fetuses

  • Ronald E. Myers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


The present paper discusses the effects of varying degrees of oxygen deprivation on fetal cardiovascular performance and on nervous system integrity. Apart from the central role played by oxygen deficiency in producing fetal brain damage and death, the vital signs changes associated with lack of oxygen serve as one of the principal methods for the moment-by-moment surveillance of the fetal condition in utero during labor and delivery. Until recently, the relationship between changes in fetal heart rate and fetal asphyxia has remained largely speculative. However, recent studies in our Laboratory have defined a more precise relationship between the severity of fetal oxygen deprivation and changes in fetal vital signs (1).


Fetal Heart Rate Brain Damage Uterine Contraction Oxygen Deprivation Placental Abruption 
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  1. 1.
    Myers, R. E., Mueller-Heubach, E., and Adamsons, K.: Predictability of the state of fetal oxygenation from quantitative analysis of components of late deceleration. Amer. J. Obstet. Gynec. 115: 1083–1094, 1973.PubMedGoogle Scholar
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Ronald E. Myers
    • 1
  1. 1.Laboratory of Perinatal Physiology, NINDSNational Institutes of HealthUSA

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