Threshold Values of Oxygen Deficiency Leading to Cardiovascular and Brain Pathological Changes in Term Monkey Fetuses
The present paper discusses the effects of varying degrees of oxygen deprivation on fetal cardiovascular performance and on nervous system integrity. Apart from the central role played by oxygen deficiency in producing fetal brain damage and death, the vital signs changes associated with lack of oxygen serve as one of the principal methods for the moment-by-moment surveillance of the fetal condition in utero during labor and delivery. Until recently, the relationship between changes in fetal heart rate and fetal asphyxia has remained largely speculative. However, recent studies in our Laboratory have defined a more precise relationship between the severity of fetal oxygen deprivation and changes in fetal vital signs (1).
KeywordsFetal Heart Rate Brain Damage Uterine Contraction Oxygen Deprivation Placental Abruption
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- 2.Ginsberg, M. D., and Myers, R. E.: Fetal brain damage following maternal carbon monoxide intoxication: An experimental study. Acta Obstet. Gynec. Scand. (in press).Google Scholar
- 3.Bito, L. Z., and Myers, R. E.: On the physiological response of the cerebral cortex to acute stress. J. Physiol. (London) 221: 349–370, 1972.Google Scholar
- 9.Reivich, M., Brann, A. W., Shapiro, H., and Myers, R. E.: Regional cerebral blood flow during prolonged partial asphyxia. In Proc. IVth Salzburg Conference on Cerebral Flow, Salzburg, Austria, 1970.Google Scholar
- 12.Myers, R. E., Valerio, M. G., Martin, D. P., and Nelson, K. B.: Perinatal brain damage: Porencephaly in a cynomolgous monkey. Biol. Neonate (in press).Google Scholar