Umbilical and Uterine Venous PO2 in Different Species during Late Gestation and Parturition

  • M. Silver
  • R. S. Comline
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


A large PO2 difference (l7–21mmHg) between uterine and umbilical venous blood is found in the cotyledonary placenta of ruminants, whereas in the equine placenta the corresponding vein-to-vein difference is only 2–4mmHg (Silver, Steven & Comline, 1973). The pig is another species with a diffuse placenta like that of the mare but without the specialised microcotyledons of the latter; simple vascular networks are found on either side of the pig placenta (Tsutsumi, 1962). Preliminary experiments have now been carried out in this species to determine the transplacental blood gas gradients and the changes which occur when maternal arterial levels are altered. In acute experiments under sodium pentobarbitone anaesthesia, vinyl catheters were inserted into uterine and umbilical vessels without disturbance of the fetus. The umbilical vessels were catheterised through small branches which were only a short distance from the cord. Because each fetus was small even near term, repeated observations were made on different fetuses rather than on a single individual.


Late Gestation Fetal Blood Ther Comparison Umbilical Vessel Uterine Vein 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • M. Silver
    • 1
  • R. S. Comline
    • 1
  1. 1.Physiological LaboratoryCambridgeEngland

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