Modeling the Coronary Circulation: Implications in the Pathogenesis of Sudden Death
Numerous experimental and clinical studies of the coronary circulation have been reported in recent years, but as yet these studies have not been tied together in any sort of overall or integrated picture. The objective of this paper is to present some preliminary work on the formulation of such an integrated picture, using the techniques of mathematical model building. Such a development serves two purposes: first of all, the many diverse experimental results may be succinctly and clearly summarized by their incorporation in the model; and secondly, the model thus developed allows for the prediction of new results, as well as yielding a better understanding of the pathogenesis of such disorders as ischemic heart disease. In the following discussion, we limit our considerations to the left ventricle, the primary site of ischemic heart disease.
KeywordsMyocardial Blood Flow Coronary Blood Flow Coronary Circulation Antianginal Drug Integrate Picture
Unable to display preview. Download preview PDF.
- 1.Winbury, M. M. Redistribution of left ventricular blood flow produced by nitroglycerine. Circ. Res. 29: (Suppl. I): 140–147, 1971.Google Scholar
- 2.Merrill, E. W. Rheology of blood. Physiol. Rev. 49:863–888, 1969.Google Scholar
- 7.Hirshorn, S., and G. A. Kaiser. Effects of changes in left ventricular end diastolic pressure on the distribution of coronary blood flow and electrical activity of the heart. Curr. Top. Surg. Res. 2:463–475, 1970.Google Scholar
- 12.Messmer, K., and H. Schmid-Schönbein, Eds. Hemodilution. S. Karger, Basel, 1972, pp. 174–183.Google Scholar
- 16.Guyton, A. C. Cardiac Output and Its Regulation. W. B. Saunders Co., Philadelphia, 1963, p. 358.Google Scholar