Modeling the Coronary Circulation: Implications in the Pathogenesis of Sudden Death

  • R. J. Gordon
  • W. Jape Taylor
  • Harvey Tritel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Numerous experimental and clinical studies of the coronary circulation have been reported in recent years, but as yet these studies have not been tied together in any sort of overall or integrated picture. The objective of this paper is to present some preliminary work on the formulation of such an integrated picture, using the techniques of mathematical model building. Such a development serves two purposes: first of all, the many diverse experimental results may be succinctly and clearly summarized by their incorporation in the model; and secondly, the model thus developed allows for the prediction of new results, as well as yielding a better understanding of the pathogenesis of such disorders as ischemic heart disease. In the following discussion, we limit our considerations to the left ventricle, the primary site of ischemic heart disease.


Myocardial Blood Flow Coronary Blood Flow Coronary Circulation Antianginal Drug Integrate Picture 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • R. J. Gordon
    • 1
  • W. Jape Taylor
    • 1
  • Harvey Tritel
    • 1
  1. 1.Department of Chemical Engineering and Division of Cardiology, Department of MedicineUniversity of FloridaGainesvilleUSA

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