Effect of Carbonic Anhydrase on the Facilitated Diffusion of CO2 through Bicarbonate Solutions

  • Shyam Suchdeo
  • Jerome S. Schultz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Over the last 10 years, several groups have given experimental evidence that carbon dioxide diffusion in aqueous solutions can be augmented by the presence of base, buffers, and catalysts for the hydration reaction of carbon dioxide with water (1,2,3). Although the mechanism for this augmentation has been presumed to be a carrier type of facilitation, no previous experimental study has covered a wide range of facilitation factors (augmented flux/ Fick’s Law flux) and at the same time presented a solution to the mathematical model which can be used to calculate the expected transport rates. This paper summarizes some of our efforts in this direction.


Carbonic Anhydrase Reaction Invariant Damkohler Number Carbon Dioxide Reaction Facilitation Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Longmuir, I.S., Foster, R.E., and Woo, C-Y., Nature, 209, 393 (1966).CrossRefGoogle Scholar
  2. 2.
    Ward, W.J. and Robb, W.L., Science, 156, 1481 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    Otto, N.C. and Quinn, J.A., Chem. Eng. Sci., 26, 949 (1971).CrossRefGoogle Scholar
  4. 4.
    Wittenberg, J.B., J. Biol. Chem., 241, 104, (1966).PubMedGoogle Scholar
  5. 5.
    Bassett, R.J. and Schultz, J.S., Biochim. Biophys. Acta, 211, 194 (1970).CrossRefGoogle Scholar
  6. 6.
    Kernohan, J.C., Biochim. Biophys. Acta, 96, 304 (1965).PubMedGoogle Scholar
  7. 7.
    Kutchai, H., Jacquez, J. A., and Mather, F.J., Biophys. J., 10, 38 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    Kreuzer, F., and Hoofd, L.J.C., Respir. Physiol., 15, 104 (1972).PubMedCrossRefGoogle Scholar
  9. 9.
    Smith, K.A., Meldon, J.H., and Colton, C.K., A.I.Ch.E. J., 19, 102 (1973).CrossRefGoogle Scholar
  10. 10.
    Goddard, J.D., Schultz, J.S., and Bassett, R.J., Chem. Eng. Sci., 25, 665 (1970).CrossRefGoogle Scholar
  11. 11.
    Suchdeo, S.R. and Schultz, J.S., Chem. Eng. Symp. Ser., 67 (114), 165 (1971).Google Scholar
  12. 12.
    Suchdeo, S.R. and Schultz, J.S., to be published in Chem. Eng. Sci.Google Scholar
  13. 13.
    Suchdeo, S.R., Ph.D. Thesis, University of Michigan, 1973, University Microfilms, Ann Arbor.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Shyam Suchdeo
    • 1
  • Jerome S. Schultz
    • 1
  1. 1.Dept. of Chemical EngineeringThe University of MichiganAnn ArborUSA

Personalised recommendations