An Analysis of the Competitive Diffusion of O2 and Co through Hemoglobin Solutions
The subject of carrier-mediated or “facilitated” transport has received widespread attention in the chemical and biological literature, especially in conjunction with diffusion across thin films or membranes. One of the simpler conceptual models for the phenomenon is based on the postulate of ordinary molecular diffusion coupled with reversible homogeneous chemical reactions. The diffu-sional flux of a transferred chemical species is thereby “mediated” or altered by reversible combination with certain mobile “carrier” species which are indigenous to the film or membrane. Any such species, which is physically restricted to the carrier-mediated transport system, will be designated here as a “non-volatile” or “non-transferred” species.
KeywordsTissue Oxygenation Reaction Layer Hemoglobin Solution Transmembrane Flux Simple Conceptual Model
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