Instrumentation and Control Techniques for Dynamic Response Experiments in Living Tissue

  • B. A. Bogue
  • W. J. DorsonJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


The development of Polarographic micro oxygen electrodes with tips less than 10μ has allowed the study of cellular and tissue oxygen levels in response to dynamic changes. Several investigators have recorded the in vivo behavior of pO2 in the cerebral cortex tissue when arterial pO2 was made to vary by a step change in the respired O2 concentration. Of particular note are the reports by Bicher (1) in the cat cerebral cortex and Metzger in the cortex of rats (2). A transient overshoot in tissue pO2 was observed during recovery from a one-minute induced hypoxia. This behavior is not predicted directly from first order models with constant metabolism (3). Subsequent analysis ascribed this behavior to delayed brain blood flow transients (4), but instantaneous flow rates were not recorded during the cited experiments.


Blood Flow Rate Controller Gain Pump Flow Rate Instantaneous Flow Rate Tissue Oxygen Level 
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  1. 1.
    Bicher, H. I., and M. H. Knisely, “Brain tissue reoxygenation time, demonstrated with a new ultramicro oxygen electrode,” J. Appl. Physiol. 28:387–390, 1970.PubMedGoogle Scholar
  2. 2.
    Metzger, H., W. Erdmann and G. Thews, “Effect of short periods of hypoxia, hyperoxia and hypercapnia on brain O2 supply,” J. Appl. Physiol. 31:751–759, 1971.PubMedGoogle Scholar
  3. 3.
    Reneau, D. D., Jr., D. F. Bruley and M. H. Knisely, “A mathematical simulation of oxygen release, diffusion, and consumption in the capillaries and tissue of the human brain,” in Chemical Engineering in Medicine and Biology, ed. by D. Hershey, p. 135–241, Plenum Press, New York, 1967.Google Scholar
  4. 4.
    Reneau, D. D., Jr., H. I. Bicher, D. F. Bruley and M. H. Knisely, “A mathematical analysis predicting cerebral tissue reoxygenation time as a function of the rate of change of effective cerebral blood flow,” Blood Oxygenation, ed. by D. Hershey, p. 175–200, Plenum Press, New York, 1970.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • B. A. Bogue
    • 1
  • W. J. DorsonJr.
    • 1
  1. 1.Engineering CenterArizona State UniversityTempeUSA

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