Intravascular Aggregation of Blood Cells and Tissue Metabolic Defects

  • Lars-Erik Gelin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Based on vital microscopy observations on the flow of blood, Knisely in the early 1940 stated the great importance of intravascular aggregation of blood cells for the pathology developing in different organs after shock, tissue injury and various diseases. The significance of aggregation of blood cells for exchange between blood and body cells as well as the exchange between body cells and blood for removal of CO2 and metabolites is still under debate.


Lactic Acid Hemorrhagic Shock Wound Fluid Contusion Injury Kidney Slice 
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  1. K. L. Appelgren, & D. H. Lewis: Capillary Flow and Capillary Transport in Dog Skeletal Muscle in Hemorrhagic Shock. Europ. Surg. Res. 4:29, 1972.CrossRefGoogle Scholar
  2. M.H. Knisely & E.H. Bloch: Microscopic observations of intravascular agglutination of red cells and consequent sludging of the blood in human diseases. Anat. Rec. 82:426, 1942.Google Scholar
  3. R. Fåhraeus & T. Lindquist: The viscosity of blood in narrow capillary tubes. Am. J.Physiol. 96:562, 1931.Google Scholar
  4. L. -E. Gelin: A method for studies of aggregation of blood cells, erythrostasis and plasma skimming in branching capillary tubes. Biorheol. 1:119, 1963.Google Scholar
  5. S. -E. Bergentz, A. Carlsten, L. -E. Gelin & J. Krebs: Hidden acidosis in experimental shock. Ann. Surg. 16:227, 1969.CrossRefGoogle Scholar
  6. Haljamäe, H.: “Hidden” cellular electrolyte responses to hemorrhagic shock and their significance. Rev. surg. 27:315, 1970.PubMedGoogle Scholar
  7. M. S. Litwin, S. E. Bergentz, A. Carlsten, L. -E. Gelin, C. -M. Ru-denstam & B. Söderholm: Hidden acidosis following intravascular red blood cell aggregation in dogs. Effect of high and low viscosity dextr an. Ann. Surg. 161:532, 1965.PubMedCrossRefGoogle Scholar
  8. B. Löfström: Intravascular aggregation and oxygen consumption. Acta Anaesth. Scand. 3:41, 1959.PubMedCrossRefGoogle Scholar
  9. L.-E. Gelin & M. Thomée: Oxygen consumption, lactic acid and LDH-production in kidney slices during shock. 7th Europ. Conf. Microcirc. Bibl. Anat. In Press.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Lars-Erik Gelin
    • 1
  1. 1.Department of Surgery IUniversity of GöteborgGöteborgSweden

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