Simulating Myocardium Oxygen Dynamics
A three-compartment model, consisting of erythrocytes, plasma, and tissue was simulated on a hybrid computer in the unsteady-state to predict myocardium oxygen tensions under normal and pathological conditions. The model includes nonequilibrium oxygen dissociation characteristics for the red cells with superimposed flow and metabolic rate changes. It was assumed that both flow velocity and metabolic rate varied as pure harmonic functions 180 degrees out of phase. Results indicate that under normal conditions, heart tissue tension remains essentially constant at a mean value rather than oscillating. It appears that this is primarily due to the frequency characteristics of the total physiological system and that myoglobin capacitance becomes important mainly at the lower heart rates.
KeywordsMetabolic Rate Oxygen Tension Heart Muscle Tissue Oxygenation Normal Heart Rate
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