Simplifying the Description of Tissue Oxygenation

  • E. N. Lightfoot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Here as in all engineering problems first priority must go to establishing orders of magnitude, both of key system parameters and of unavoidable uncertainties. Once this is done it is possible to develop a solution providing the maximum degree of simplicity consistent with the need for accuracy. Accordingly we begin by defining a model, the modified Krogh tissue cylinder of Fig. 1, and establishing representative dimensions and other characteristics (see Fig. 1 and Table 1).


Oxygen Tension Tissue Oxygenation Axial Diffusion Tissue Cylinder Oxyhemoglobin Dissociation Curve 
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  1. Aroesty, J. and J. F. Gross, Microvasc. Res. 2, 247 (1970).PubMedCrossRefGoogle Scholar
  2. Crandall, E. D. and R. W. Flumerfelt, in Chemical Engineering in Biology and Medicine, D. Hershey, Ed., Plenum (1967).Google Scholar
  3. Dindorf, J. A., E. N. Lightfoot, and K. A. Solen, Chem. Eng. Prog. Symp. Series # 114, pp. 75–87 (1971).Google Scholar
  4. Keller, K. H. and S. K. Friedlander, Chem. Eng. Prog. Symp. Series, #66, 19 (1966).Google Scholar
  5. Longo, L. D., G. G. Power, and R. E. Foster, II, J. Appl. Physiol. 26, 360 (1969).PubMedGoogle Scholar
  6. Reneau, D. D., D. F. Bruley, and M. H. Khisely, A.I.Ch.E. J. 15, 916–925 (1969).CrossRefGoogle Scholar
  7. Spaeth, E. E., Blood Oxygenation, CRC Critical Reviews in Bio-engineering (In press).Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • E. N. Lightfoot
    • 1
  1. 1.Department of Chemical EngineeringUniversity of WisconsinUSA

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