Capillary-Tissue Exchange Kinetics: Diffusional Interactions Between Adjacent Capillaries

  • Carl A. Goresky
  • Harry L. Goldsmith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


On the basis of their blood supply, organs in the mammalian body can be classified into two types: well-perfused and poorly perfused. The well-perfused organs include liver, heart, lungs, kidneys, and brain; and the poorly perfused organs include skin and subcutaneous tissue, and resting muscle.


Dilution Curve Countercurrent Flow Label Water Cine Film Stagger Entrance 


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  1. 1.
    Goresky, C.A. A linear method for determining liver sinusoidal and extravascular volumes. Amer. J. Physiol. 204: 626–640, 1963.Google Scholar
  2. 2.
    Ziegler, W.H., and C.A. Goresky. Transcapillary exchange in the working left ventricle in the dog. Circ. Res. 29: 181–207, 1971.PubMedGoogle Scholar
  3. 3.
    Rappaport, A.M. Normal microcirculation of the mammalian liver (cine film). Microvasc. Res. 4: 329, 1972. The film was obtained from Dr. A.M. Rappaport, Department of Physiology, university of Toronto, Toronto, Ontario.Google Scholar
  4. 4.
    Kot, P.A. Microcirculation of the frog lung. High speed cine film, obtained from Dr. P.A. Kot, Georgetown Medical School, Washington, D.C.Google Scholar
  5. 5.
    Perl, W., and F.P. Chinard. A convection-diffusion model of indicator transport through an organ. Circ. Res. 22: 273–298, 1968.PubMedGoogle Scholar
  6. 6.
    Bassingthwaighte, J.B., T.J. Knopp, and J.B. Hazelrig. A concurrent flow model for capillary-time exchanges. In: Capillary Permeability (Alfred Benzon Symposium II), ed. by C. Crone and N.A. Lassen. Munksgaard, Copenhagen 1970 (60–80).Google Scholar
  7. 7.
    Goresky, C.A., W.H. Ziegler, and G.G. Bach. Capillary exchange modeling: barrier-limited and flow-limited distribution. Circ. Res. 27: 739–764, 1970.PubMedGoogle Scholar
  8. 8.
    Sobin, S.S., H.T. Tremer, and Y.C. Fung. Morphometric basis of the sheet flow concept of the pulmonary alveolar microcirculation in the cat. Circ. Res. 26: 397–414, 1970.PubMedGoogle Scholar
  9. 9.
    Goresky, C.A., G.G. Bach, and B.E. Nadeau. On the uptake of materials by the intact liver: the transport and net removal of galactose. J. Clin. Invest. In Press (May 1973).Google Scholar
  10. 10.
    Hellberg, K., A. Rickart, and R. Bing. Direct observations of the coronary microcirculation in the arrested and beating heart (high speed cine). Fed. Proc. 30: 613a, 1971. The film was obtained from Dr. R. Bing, Huntington Memorial Hospital, Pasadena, California.Google Scholar
  11. 11.
    Levitt, D.G. Theoretical model of capillary exchange incorporating interactions between capillaries. Amer. J. Physiol. 220: 250–255, 1971.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Carl A. Goresky
    • 1
  • Harry L. Goldsmith
    • 1
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada

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