Augmentation of Tissue Oxygen by Dimethyl Sulfoxide and Hydrogen Peroxide

  • Bert Myers
  • William Donovan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Dimethyl sulfoxide (DMSO) increases the permeability of tissue and has been reported to aid in the transport of drugs through intact skin. 1, 2 These experiments were designed to see if the drug would transport oxygen in the form of hydrogen peroxide (H202) through skin. A mass spectrometer was used to measure tissue gas levels (P02, PC02, PN2).


Normal Skin Skin Flap Intact Skin Central Needle Island Flap 
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    Kligman, A.M. Topical pharmacology and toxicology of DMSO, JAMA 193:140 1965.Google Scholar
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    Leake, C.D. Biological actions of dimethyl sulfoxide. Ann. N.Y. Acad. Sci. 141:1–671 1967.CrossRefGoogle Scholar
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    Wilson, W.R., Toomey, J.M., and Owens, G. Continuous measurement of local PO2 and PC O2 during the creation of bipedicle skin flaps in dogs. Surg. Forum 22:495 1972.Google Scholar
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    Hunt, T. K., Linsey, M., Sonne, M., and Jawetz, E. Oxygen tension and wound infection. Surg. Forum 22:47 1972.Google Scholar
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    Bethman, W. and Schottke, C. Action of local oxygen application on healing of pedicle flaps. Zbl. Chir. 92:ll1235 1967.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Bert Myers
    • 1
  • William Donovan
    • 1
  1. 1.Dept. of Surgery LSU School of Medicine and the Vet. Admin. Hosp.New OrleansUSA

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