Voltage-Dependent Gating

Gating Current Measurement and Interpretation
  • Francisco Bezanilla
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


The voltage dependence of ionic conductances such as those of sodium and potassium is the result of the voltage influence on the open and closed times of individual channels. This means that an understanding of the voltage dependence of the fraction of open channels will help to correlate the microscopic (single-channel) and macroscopic properties (total ionic current). The question arises as to how the channel goes from the open to the closed configuration and, in particular, how the voltage across the membrane regulates the state of the channel, a process known as voltage gating.


Sodium Channel Closed State Voltage Dependence Sodium Current Membrane Capacitance 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Francisco Bezanilla
    • 1
    • 2
  1. 1.Department of PhysiologyAhmanson Laboratory of NeurobiologyLos AngelesUSA
  2. 2.Jerry Lewis Neuromuscular Research CenterUniversity of California at Los AngelesLos AngelesUSA

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