A Channel Model for Development of the Fertilization Membrane in Sea Urchin Eggs

  • Gerald Ehrenstein
  • Richard FitzHugh
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


The channels we consider in this chapter have not yet been observed. They are part of a model we have developed to describe the increase in cytosolic calcium that occurs within an egg following fertilization. Before describing the model, it is useful to provide some background. First, we outline the processes that occur following fertilization of a sea urchin egg, in order to put into context the role of the increase in cytosolic calcium. Then we summarize the experimental evidence that guided the development of the model. Finally, we describe the model in words and in equations and indicate some of its predictions.


Free Calcium Cytosolic Calcium Cytosolic Free Calcium Cytosolic Calcium Concentration Theoretical Test 


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  1. Chambers, E. L., 1980, Fertilization and cleavage of eggs of the sea urchin, Lytechinus variegatus, in calcium-free seawater, Eur. J. Cell Biol. 22:476.Google Scholar
  2. Dale, B., DeFelice, L. J., and Ehrenstein, G., 1985, Injection of a soluble sperm fraction into sea-urchin eggs triggers the cortical reaction. Experientia 41:1068.PubMedCrossRefGoogle Scholar
  3. Epel, D., 1982, The cascade of events initiated by rises in cytosolic Ca+2 and pH following fertilization in sea urchin eggs, in Ions, Cell Proliferation, and Cancer, (A. L. Boynton, W. L. McKeehan, J. F. Whitfield, eds.), Academic Press, New York, pp. 327–339.Google Scholar
  4. Gilkey, J. C., Jaffe, L. F., Ridgeway, E. B., and Reynolds, G. T., 1978, A free calcium wave traverses the activating egg of the medaka, Oryzias latipes, J. Cell Biol. 76:448–466.PubMedCrossRefGoogle Scholar
  5. Poenie, M., Patton, C., and Epel, D., 1982, Use of calcium precipitants during fixation of sea urchin eggs for electron microscopy: Search for the calcium store, J. Cell Biol. 95:161a.Google Scholar
  6. Steinhardt, R. A., Zucker, R., and Schatten, G., 1977, Intracellular calcium release at fertilization in the sea urchin egg, Dev. Biol. 58: 185–196.PubMedCrossRefGoogle Scholar
  7. Whitaker, M., and Irvine, R. F., 1984, Inositol 1,4,5-trisphosphate microinjection activates sea urchin eggs, Nature 312:636–639.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Gerald Ehrenstein
    • 1
  • Richard FitzHugh
    • 1
  1. 1.Laboratory of Biophysics, NINCDSNational Institutes of HealthBethesdaUSA

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