Amiloride-Sensitive Epithelial Sodium Channels

  • Dale J. Benos
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)

Abstract

Electrically high-resistance epithelia actively transport sodium from the luminal side to the blood (Macknight et al., 1980). The first step in this transepithelial movement of Na+ is the facilitated diffusion of this ion across the luminal or apical membrane down its electrochemical potential energy gradient. This particular transport pathway is rate limiting for the overall transport, is regulated hormonally, and is inhibited by the diuretic drug amiloride. Single-site turnover numbers deduced from current-noise experiments (106 ionsJsec) are consistent with a channel or pore-type mechanism (Lindemann and Van Driessche, 1977). Fuchs et al. (1977) and Van Driessche and Lindemann (1979) found that under their experimental conditions, Na+ permeation through these channels could be adequately described by an electrodiffusion model in which the passive movement of Na+ obeys the independence principle.

Keywords

Permeability Luminal Sponge Pyrimidine Aldosterone 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dale J. Benos
    • 1
  1. 1.Department of Physiology and Biophysics, Laboratory of Human Reproduction and Reproductive BiologyHarvard Medical SchoolBostonUSA

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