Neurotrophic Effects of in Vitro Innervation of Cultured Muscle Cells. Modulation of Ca2+-Activated K+ Conductances

  • Benjamin A. Suarez-Isla
  • Stanley I. Rapoport
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


The trophic influence of nerve on muscle is expressed as several complex changes of the muscle plasma membrane (McArdle, 1983). Muscle denervation studies (Luco and Eyzaguirre, 1955; Thesleff, 1974) showed that cutting of the nerve decreased the membrane resting potential, increased the specific membrane resistance, and induced the appearance of hyperpolarizing afterpotentials. Denervation also decreases the sensitivity to blockage by tetrodotoxin of the action potential mechanism (Thesleff, 1974) and promotes the insertion of acetylcholine receptors into extra-junctional regions (Berg and Hall, 1975).


Spinal Cord Neuron Neurotrophic Effect Muscle Innervation Propagate Action Potential Trophic Influence 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Benjamin A. Suarez-Isla
    • 1
  • Stanley I. Rapoport
    • 1
  1. 1.Laboratory of Neurosciences, National Institute on AgingNational Institutes of HealthBethesdaUSA

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