The β-Cell Bursting Pattern and Intracellular Calcium

  • Illani Atwater
  • John Rinzel
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


Mammalian islets of Langerhans are made up principally of insulin-secreting β cells but also contain glucagon-secreting α cells, somatostatin-secreting δ cells, and polypeptide-secreting PP cells as well as sympathetic and parasympathetic nerve terminals and capillary-associated endothelial cells. The islets of Langerhans from mouse are convenient for electrophysiological studies because they are large (up to 1 mm in diameter), easily distinguished from the surrounding pancreatic tissue, and contain a large proportion of β cells (about 85%), which are mainly located in the center of the islet.


Relative Duration Burst Frequency Burst Period Burst Pattern Voltage Deflection 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Illani Atwater
    • 1
  • John Rinzel
    • 2
  1. 1.Laboratory of Cell Biology and Genetics, NIADDKNational Institutes of HealthBethesdaUSA
  2. 2.Mathematical Research Branch, NIADDKNational Institutes of HealthBethesdaUSA

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