Kinetic Models and Channel Fluctuations

  • Osvaldo Alvarez
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


In this chapter the essentials of the kinetics of opening and closing of ionic channels will be discussed. I present several kinetic models and show the type of single channel records to be expected for each model and how to calculate kinetic constant from these records. The models I discuss are two state channels, three-state channels with three conductances, and three-state channels with only two conductances. The basic ideas for this chapter were taken from Dionne and Leibowitz (1982) and Ehrenstein et al. (1974).


Open Channel Closed State Closed Time Current Record Record Pointer 
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  1. Dionne, V. E., and Leibowitz, M. D., 1982, Acetylcholine receptor kinetics, a description from single-channel current at snake neuromuscular junctions, Biophys. J. 39:253–261.PubMedCrossRefGoogle Scholar
  2. Ehrenstein, G., Blumenthal, R., Latorre, R., and Lecar, H., 1974, Kinetics of the opening and closing of individual excitability-inducing material, J. Gen. Physiol. 63:707–721.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Osvaldo Alvarez
    • 1
    • 2
  1. 1.Departamento de Biología, Facultad de CienciasUniversidad de ChileSantiagoChile
  2. 2.Centro de Estudios Cientifícos de SantiagoSantiagoChile

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