Ion Channel Reconstitution Why Bother?
Twenty years ago, membrane transport research was experiencing an exciting and, in some ways, an intellectually chaotic time—a time when the extreme multiplicity of membrane transporters was being uncovered phenomenologically, a time when it seemed, at least to the bewildered student, that each different type of specialized cell carried its own unique constellation of dedicated solute “carriers” (as we then termed them). To that student, it was clear that the experimentalists often rubbing shoulders in physiology departments—the Na+ pumpers, the sugar carriers, the oxidative phosphorylators, the renal electrolyte balancers, the bacterial energizers—that these people were working on totally different problems; and this list ignores the electrophysiologists.
KeywordsChannel Protein Electric Organ Lipid Surface Native Membrane Planar Lipid Bilayer
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