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Mechanotransducing Ion Channels

  • Frederick Sachs
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)

Abstract

Mechanical transduction is the most widespread sensory modality in animals. Specialized organs of the cochlea (Hudspeth, 1983) and vestibular system provide our sense of hearing and local gravity. Our sense of touch and vibration, particularly in the skin, is mediated by a variety of specialized mechanosensors and possibly free nerve endings (Iggo and Andres, 1982). Muscle tension is transduced by Ia afferent nerves in muscle spindles, while tendon tension is transduced by Golgi tendon organs. Joint position is transduced by poorly understood receptors in the joint capsule. The inflation of hollow organs is reported by sensory nerves of the autonomic nervous system, although the location of the actual transducers is not known and may reside in nerve cells, muscle cells, or other types of supporting cells. Inflation of blood vessels is used to measure blood pressure. Inflation of the lung, gut, bladder, mammary glands, and probably cerebrospinal fluid all provides essential feedback for autonomic regulation. Osmoregulation at the systemic level and cell volume itself (Kregenow, 1981) are likely to be controlled by feedback from membrane tension.

Keywords

Hair Cell Membrane Tension Free Nerve Ending Golgi Tendon Organ Mechanoelectrical Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Auerbach, A., and Sachs, F., 1984, Kinetics and conductance properties of gaps within bursts of nicotinic ion channel activity, Biophys. J. 45:187–198.PubMedCrossRefGoogle Scholar
  2. Brehm, P., Kullberg, R., and Moody-Corbett, F., 1984, Properties of nonjunctional acetylcholine receptor channels on innervated muscle of Xenopus Laevis, J. Physiol. (Lond.) 350:631–648.Google Scholar
  3. Colquhoun, D., and Hawkes, A. G., 1981, On the stochastic properties of single ion channels, Proc. R. Soc. Lond. [Biol.] 211:205–235.CrossRefGoogle Scholar
  4. Corey, D., and Hudspeth, A. J., 1983, Kinetics of the receptor current in bullfrog saccular hair cells, J. Neurosci. 3:962–976.PubMedGoogle Scholar
  5. Edwards, C., 1983, The ionic mechanisms underlying the receptor potential in mechano-receptors, in The Physiology of Excitable Cells (A. D. Grinnel and W. J. Moody, eds.), Alan R. Liss, New York, pp. 497–503.Google Scholar
  6. Edwards, C., Ottoson, D., Rydqvist, B., and Swerup, C., 1981, The permeability of the transducer membrane of the crayfish stretch receptor to calcium and other divalent ions, Neuroscience 6:1455–1460.PubMedCrossRefGoogle Scholar
  7. Evans, E. A., and Hochmuth, R. M., 1973, Mechano-chemical properties of membrane, in Current Topics in Membrane Transport (F. Bronner and A. Kleinzeller, eds.), Academic Press, New York, pp. 1–64.Google Scholar
  8. Evans, E. A., Waugh, R., and Melnik, L., 1976, Elastic area compressibility modulus of red cell membrane, Biophys. J. 16:585–595.PubMedCrossRefGoogle Scholar
  9. Gross, D., Williams, W. S., and Connor, J. A., 1983, Theory of electromechanical effects in nerve, Cell. Mol. Neurobiol. 3:89–111.PubMedCrossRefGoogle Scholar
  10. Guharay, F., and Sachs, F., 1984a, Stretch activated single ion-channel currents in tissue-cultured embryonic chick skeletal muscle, J. Physiol. (Lond.) 352:685–701.Google Scholar
  11. Guharay, F., and Sachs, F., 1984b, Mechano-transducer ion channels in chick skeletal muscle: The effects of extracellular pH, J. Physiol. (Lond.) 363:119–134.Google Scholar
  12. Guharay, F., and Sachs, F., 1985, Mechano-receptor ion channels are not nicotinic, Biophys. J. 47:2039.Google Scholar
  13. Hamill, O. P., 1983, Potassium and chloride channels in red blood cells, in Single-Channel Recording (B. Sakmann and E. Neher, eds.), Plenum Press, New York, pp. 451–471.Google Scholar
  14. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J., 1981, Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches, Pfluegers Arch. 391:85–100.CrossRefGoogle Scholar
  15. Helfrich, W., 1973, Elastic properties of lipid bilayers: Theory and possible experiments, Z. Naturforsch. 28C:693–703.Google Scholar
  16. Hudspeth, A. J., 1983, Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system, Annu. Rev. Neurosci. 6:187–215.PubMedCrossRefGoogle Scholar
  17. Iggo, A., and Andres, K. H., 1982, Morphology of cutaneous receptors, Annu. Rev. Neurosci. 5:1–31.PubMedCrossRefGoogle Scholar
  18. Kistler, J., Stroud, R. M., Klymkowsky, M. W., Lalancette, R. A., and Fairclough, R. H., 1982, Structure and function of an acetylcholine receptor, Biophys. J. 37:371–383.PubMedCrossRefGoogle Scholar
  19. Kregenow, F., 1981, Osmoregulatory salt transporting mechanisms: Control of cell volume in anisotropic media, Annu. Rev. Physiol. 43:493–505.PubMedCrossRefGoogle Scholar
  20. Kwok, R., and Evans, E. A., 1981, Thermoelasticity of large lecithin bilayer vesicles, Biophys. J. 35:637–652.PubMedCrossRefGoogle Scholar
  21. Lis, L. J., McAlister, M., Fuller, N., Rand, R. P., and Parsegian, V. A, 1982, Measurement of the lateral compressibility of several phospholipid bilayers, Biophys. J. 37:667–672.PubMedGoogle Scholar
  22. Naftalin, L., 1965, Some new proposals regarding acoustic transmission and transduction, Cold Spring Harbor Symp. Quant. Biol. 30:169–180.PubMedCrossRefGoogle Scholar
  23. Ohmori, H., 1984, Studies of ionic currents in the isolated vestibular hair cell of the chick, J. Physiol. (Lond.) 350:561–581.Google Scholar
  24. O’Leary, D. P., 1970, An electrokinetic model of transduction in the semicircular canal, Biophys. J. 10:859–875.PubMedCrossRefGoogle Scholar
  25. Sachs, F., 1984, The noise produced by patch electrodes: A model, Biophys. J. 45:57a.CrossRefGoogle Scholar
  26. Sachs, F., Neil, J., and Barkakati, N., 1982, Automated analysis of single channel data, Pfluegers Arch. 395:331–340.CrossRefGoogle Scholar
  27. Sakmann, B., and Neher, E., 1983, Geometric parameters of pipettes and membrane patches, in Single-Channel Recording (B. Sakmann and E. Neher, eds.), Plenum Press, New York, pp. 37–51.Google Scholar
  28. Teorell, T., 1971, A biophysical analysis of mechano-electrical transduction, in Principles of Receptor Physiology, (W. R. Loewenstein, ed.), Springer-Verlag, New York, pp. 291–339.CrossRefGoogle Scholar
  29. Weber, K., and Osborne, M., 1981, Microtubule and intermediate filament networks in cells viewed by immunofluorescence microscopy, in Cytoskeletal Elements and Plasma Membrane Organization, (G. Poste and G. Nicholson, eds.), Elsevier/North-Holland, Amsterdam, pp. 1–55.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Frederick Sachs
    • 1
  1. 1.Department of Biophysics, School of MedicineState University of New York at BuffaloBuffaloUSA

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