Intracellular Protein Topogenesis
A cell contains millions of protein molecules, which are continually being synthesized and degraded. At homeostasis, a given species of protein is represented by a characteristic number of molecules that is kept constant within a narrow range. Very little is known about the accounting procedures of the cell, i.e., how it balances and controls biosynthesis and biodegradation.
KeywordsIntegral Membrane Protein Protein Translocation Microsomal Membrane Signal Recognition Particle Translocation System
Unable to display preview. Download preview PDF.
- Anderson, D. J., Mostov, K. E., and Blobel, G., 1983, Mechanisms of integration for de novo synthesized polypeptides into membranes. Signal recognition particle is required for the integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5,Proc, Natl. Acad. Sci. U.S.A. 80:7249–7253.CrossRefGoogle Scholar
- Blobel, G., 1979, Extralysosomal compartments for the turnover of intracellular macro-molecules, in:Limited Proteolysis in Microorganisms (G. N. Cohen, H. Holzer, eds.), U.S. Department of Health, Education and Welfare, Washington, pp. 167–169.Google Scholar
- Mueller, M., Ibrahimi, I., Chang, C. N., Walter, P., and Blobel, G., 1982, A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum, J. Biol. Chem. 257:11860–11863.Google Scholar
- Walter, P., and Blobel, G., 1981, Translocation of proteins across the endoplasmic reticulum. III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes, J. Cell Biol. 91:557–561.PubMedCrossRefGoogle Scholar