Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver

  • John R. Williamson
  • Suresh K. Joseph
  • Kathleen E. Coll
  • Andrew P. Thomas
  • Arthur Verhoeven
  • Marc Prentki
Part of the New Horizons in Therapeutics book series (NHTH)


Although it has been recognized for many years that changes of the intracellular free Ca2+ concentration by a variety of agonists form an important signaling device for regulation of cell function, the source of the Ca2+ and the molecular events regulating receptor-mediated changes of cellular calcium homeostasis have remained recalcitrant problems despite much effort directed towards their elucidation. However, advances made along a number of different lines have contributed towards the rapid increase of knowledge in this area. These include on the one hand the development of fluorescent Ca2+ indicators such as Quin 2 (Tsien, 1983) and more recently Fura 2 (Grynkiewicz et al., 1985), which allow kinetic measurements of changes in the cytosolic free Ca2+ concentration of isolated cells, and on the other hand the elucidation of the signaling roles of two new intracellular second messengers, namely, inositol trisphosphate and diacylglycerol (for reviews see Nishizuka et al., 1984; Nishizuka, 1984a; Berridge and Irvine, 1984; Williamson et al., 1985; Williamson, 1986).


Phorbol Ester Inositol Trisphosphate Insulinoma Cell Calcium Pool Vasopressin Antagonist 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John R. Williamson
    • 1
  • Suresh K. Joseph
    • 1
  • Kathleen E. Coll
    • 1
  • Andrew P. Thomas
    • 1
  • Arthur Verhoeven
    • 1
  • Marc Prentki
    • 1
  1. 1.Department of Biochemistry and BiophysicsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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